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Prevalence of lower extremity peripheral arterial disease in individuals with chronic immune mediated inflammatory disorders.

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dc.contributor.author Agüero, Fernando H., 1968-
dc.contributor.author Gonzalez Zobl, Griselda
dc.contributor.author Baena Díez, Jose M.
dc.contributor.author Roman Degano, Irene
dc.contributor.author Garcia Gil, Maria
dc.contributor.author Alzamora, María Teresa
dc.contributor.author Marrugat de la Iglesia, Jaume
dc.contributor.author Comas Cufí, Marc
dc.contributor.author Pera, Guillem
dc.contributor.author Elosua Llanos, Roberto
dc.contributor.author Ramos, Rafel
dc.contributor.author Grau Magaña, Maria
dc.date.accessioned 2015-10-14T10:09:02Z
dc.date.available 2015-10-14T10:09:02Z
dc.date.issued 2015
dc.identifier.citation Agüero F, González-Zobl G, Baena-Díez JM, Dégano IR, Garcia-Gil M, Alzamora MT. Prevalence of lower extremity peripheral arterial disease in individuals with chronic immune mediated inflammatory disorders. Atherosclerosis. 2015 Sep;242(1):1-7. DOI: 10.1016/j.atherosclerosis.2015.06.054.
dc.identifier.issn 0021-9150
dc.identifier.uri http://hdl.handle.net/10230/24844
dc.description.abstract OBJECTIVE: To compare the prevalence of lower extremity peripheral artery disease (PAD) and to assess whether age-associated progression in ankle-brachial index (ABI) differs between individuals with chronic immune-mediated inflammatory diseases (CIID) and the general population. METHODS: Pooled analysis with data from individuals aged 50 years and older with ABI measurements, obtained from population-based cross-sectional studies conducted in Catalonia (Spain). Information on three CIID diagnoses (i.e., inflammatory bowel disease, systemic connective tissue disorders, and inflammatory polyarthropathies and spondylopathies, considered as one entity for purposes of analysis) was obtained from electronic medical records. To ascertain the statistical association between PAD and CIID, logistic regression models were fitted and adjusted for age, sex, and cardiovascular risk factors. We tested the interaction between age and CIID diagnosis for ABI values. RESULTS: We included 8799 individuals, 312 (3.6%) with CIID. The age-standardized prevalence of PAD was higher in the CIID group (12% vs. 6% in general population, p = 0.001), and the model adjusted for age, sex, and cardiovascular risk factors also showed higher risk in individuals with CIID [Odds Ratio (95% confidence interval) = 1.65 (1.15-2.38); p = 0.007]. The inflammatory polyarthropathies/spondylopathies diagnosis was significantly associated with PAD in the fully adjusted model [1.80 (1.18-2.75); p = 0.006]. The atherosclerotic process was accelerated in individuals with CIID, compared to the general population (p for interaction<0.001). CONCLUSION: In individuals with CIID, age-standardized prevalence of PAD was significantly higher than in the general population and the atherosclerotic process was accelerated. However, only inflammatory polyarthropathies/spondylopathies was associated with significant risk of PAD.
dc.description.sponsorship Supported by grants from the Instituto de Salud Carlos III FEDER (Programa HERACLES RD12/0042; RedIAPP RD12/0005; CP12/ 03287), AGAUR (2014 SGR 240 and 2011BP-B00169 postdoctoral contract to IRD eBeatriu de Pinos Program co- financed by the European Commission), Health Research Fund (FIS 2003/HERMES PI20471; PI070403; ETES: I07/90415; FIS11/06765); and Ministry of Education and Science (SAF2003/1240).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Atherosclerosis. 2015 Sep;242(1):1-7
dc.rights © 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/). http://dx.doi.org/10.1016/j.atherosclerosis.2015.06.054
dc.rights.uri http://creativecommons.org/licenses/by-ncnd/4.0/
dc.subject.other Reumatisme -- Epidemiologia
dc.subject.other Malalties vasculars perifèriques
dc.title Prevalence of lower extremity peripheral arterial disease in individuals with chronic immune mediated inflammatory disorders.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.atherosclerosis.2015.06.054
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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