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Sleep disorders in parkinsonian and nonparkinsonian LRRK2 mutation carriers

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dc.contributor.author Pont-Sunyer, Claustre Pont-Sunyer
dc.contributor.author Iranzo, Alex
dc.contributor.author Gaig, Carles
dc.contributor.author Fernández-Arcos, Ana
dc.contributor.author Vilas, Dolores
dc.contributor.author Valldeoriola, Francesc
dc.contributor.author Compta, Yaroslau
dc.contributor.author Fernández-Santiago, Ruben
dc.contributor.author Fernández, Manel
dc.contributor.author Bayés, Angels
dc.contributor.author Calopa, Matilde
dc.contributor.author Casquero, Pilar
dc.contributor.author De Fàbregues, Oriol
dc.contributor.author Jaumà, Serge
dc.contributor.author Puente Periz, Victor Manuel
dc.contributor.author Salamero, Manel
dc.contributor.author Martí, Maria José
dc.contributor.author Santamaría, Joan
dc.contributor.author Tolosa, Eduard
dc.date.accessioned 2015-10-07T07:33:25Z
dc.date.available 2015-10-07T07:33:25Z
dc.date.issued 2015
dc.identifier.citation Pont-Sunyer C, Iranzo A, Gaig C, Fernández-Arcos A, Vilas D, Valldeoriola F. et al. Sleep disorders in parkinsonian and nonparkinsonian LRRK2 mutation carriers. PLoS One. 2015 Jul 15;10(7):e0132368. doi: 10.1371/journal.pone.0132368.
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/24806
dc.description.abstract OBJECTIVE: In idiopathic Parkinson disease (IPD) sleep disorders are common and may antedate the onset of parkinsonism. Based on the clinical similarities between IPD and Parkinson disease associated with LRRK2 gene mutations (LRRK2-PD), we aimed to characterize sleep in parkinsonian and nonmanifesting LRRK2 mutation carriers (NMC). METHODS: A comprehensive interview conducted by sleep specialists, validated sleep scales and questionnaires, and video-polysomnography followed by multiple sleep latency test (MSLT) assessed sleep in 18 LRRK2-PD (17 carrying G2019S and one R1441G mutations), 17 NMC (11 G2019S, three R1441G, three R1441C), 14 non-manifesting non-carriers (NMNC) and 19 unrelated IPD./nRESULTS: Sleep complaints were frequent in LRRK2-PD patients; 78% reported poor sleep quality, 33% sleep onset insomnia, 56% sleep fragmentation and 39% early awakening. Sleep onset insomnia correlated with depressive symptoms and poor sleep quality. In LRRK2-PD, excessive daytime sleepiness (EDS) was a complaint in 33% patients and short sleep latencies on the MSLT, which are indicative of objective EDS, were found in 71%. Sleep attacks occurred in three LRRK2-PD patients and a narcoleptic phenotype was not observed. REM sleep behavior disorder (RBD) was diagnosed in three LRRK2-PD. EDS and RBD were always reported to start after the onset of parkinsonism in LRRK2-PD. In NMC, EDS was rarely reported and RBD was absent. When compared to IPD, sleep onset insomnia was more significantly frequent, EDS was similar, and RBD was less significantly frequent and less severe in LRRK2-PD. In NMC, RBD was not detected and sleep complaints were much less frequent than in LRRK2-PD. No differences were observed in sleep between NMC and NMNC. CONCLUSIONS: Sleep complaints are frequent in LRRK2-PDand show a pattern that when compared to IPD is characterized by more frequent sleep onset insomnia, similar EDS and less prominent RBD. Unlike in IPD, RBD and EDS seem to be not markers of the prodromal stage of LRRK2-PD.
dc.description.sponsorship This manuscript received support through the grant number 061130/31 from "La Fundació la Marató de TV3" to Eduard Tolosa. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartof PLoS One. 2015 Jul 15;10(7):e0132368
dc.rights © 2015 Pont-Sunyer et al. This is an open access article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Trastorns del son
dc.subject.other Parkinson, Malaltia de
dc.title Sleep disorders in parkinsonian and nonparkinsonian LRRK2 mutation carriers
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0132368
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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