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Emotion processing in joint hypermobility: A potential link to the neural bases of anxiety and related somatic symptoms in collagen anomalies

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dc.contributor.author Mallorquí Bagué, Joaquim
dc.contributor.author Bulbena Vilarrasa, Antonio
dc.contributor.author Roé -Vellvé, Núria
dc.contributor.author Hoekzema, Elseline
dc.contributor.author Carmona, Susanna
dc.contributor.author Barba-Müller, Erika
dc.contributor.author Fauquet, Jordi
dc.contributor.author Pailhez, Guillem
dc.contributor.author Vilarroya, Óscar
dc.date.accessioned 2015-04-09T10:21:05Z
dc.date.available 2015-04-09T10:21:05Z
dc.date.issued 2015
dc.identifier.citation Mallorquí-Bagué N, Bulbena A, Roé-Vellvé N, Hoekzema E, Carmona S, Barba-Müller E. et al. Emotion processing in joint hypermobility: A potential link to the neural bases of anxiety and related somatic symptoms in collagen anomalies. Eur Psychiatry. 2015 Feb 12;30(4):454-8. doi: 10.1016/.
dc.identifier.issn 0924-9338
dc.identifier.uri http://hdl.handle.net/10230/23374
dc.description.abstract BACKGROUND: Joint hypermobility syndrome (JHS) has repeatedly been associated with anxiety and anxiety disorders, fibromyalgia, irritable bowel syndrome and temporomandibular joint disorder. However, the neural underpinnings of these associations still remain unclear. This study explored brain responses to facial visual stimuli with emotional cues using fMRI techniques in general population with different ranges of hypermobility. METHODS: Fifty-one non-clinical volunteers (33 women) completed state and trait anxiety questionnaire measures, were assessed with a clinical examination for hypermobility (Beighton system) and performed an emotional face processing paradigm during functional neuroimaging. RESULTS: Trait anxiety scores did significantly correlate with both state anxiety and hypermobility scores. BOLD signals of the hippocampus did positively correlate with hypermobility scores for the crying faces versus neutral faces contrast in ROI analyses. No results were found for any of the other studied ROIs. Additionally, hypermobility scores were also associated with other key affective processing areas (i.e. the middle and anterior cingulate gyrus, fusiform gyrus, parahippocampal region, orbitofrontal cortex and cerebellum) in the whole brain analysis. CONCLUSIONS: Hypermobility scores are associated with trait anxiety and higher brain responses to emotional faces in emotion processing brain areas (including hippocampus) described to be linked to anxiety and somatic symptoms. These findings increase our understanding of emotion processing in people bearing this heritable variant of collagen and the mechanisms through which vulnerability to anxiety and somatic symptoms arises in this population.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier Masson
dc.relation.ispartof European Psychiatry. 2015 Feb 12;30(4):454-8
dc.rights © Elsevier http://dx.doi.org/10.1016/j.eurpsy.2015.01.004I
dc.subject.other Ansietat
dc.subject.other Fibromialgia
dc.subject.other Emocions
dc.title Emotion processing in joint hypermobility: A potential link to the neural bases of anxiety and related somatic symptoms in collagen anomalies
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.eurpsy.2015.01.004
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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