Welcome to the UPF Digital Repository

Influence of δ-opioid receptors in the behavioral effects of nicotine

Show simple item record

dc.contributor.author Berrendero Díaz, Fernando, 1971-
dc.contributor.author Plaza-Zabala, Ainhoa, 1982-
dc.contributor.author Galeote González, Lola
dc.contributor.author Flores de los Heros, África, 1985-
dc.contributor.author Bura, S. Andreea, 1978-
dc.contributor.author Kieffer, Brigitte L.
dc.contributor.author Maldonado, Rafael, 1961-
dc.date.accessioned 2015-03-27T08:00:53Z
dc.date.available 2015-03-27T08:00:53Z
dc.date.issued 2012
dc.identifier.citation Berrendero F, Plaza-Zabala A, Galeote L, Flores Á, Bura SA, Kieffer BL, Maldonado R. Influence of δ-opioid receptors in the behavioral effects of nicotine. Neuropsychopharmacology. 2012 Sep; 37(10): 2332-44. DOI: 10.1038/npp.2012.88
dc.identifier.issn 0893-133X
dc.identifier.uri http://hdl.handle.net/10230/23297
dc.description.abstract Multiple studies in animal models and humans suggest that the endogenous opioid system is an important neurobiological substrate for nicotine addictive properties. In this study, we evaluated the participation of δ-opioid receptors in different behavioral responses of nicotine by using δ-opioid receptor knockout mice. Acute nicotine administration induced hypolocomotion and antinociception in wild-type mice, which were similar in knockout animals. The development of tolerance to nicotine-induced antinociception was also similar in both genotypes. In agreement, the expression and functional activity of δ-opioid receptors were not modified in the different layers of the spinal cord and brain areas evaluated after chronic nicotine treatment. The somatic manifestation of the nicotine withdrawal syndrome precipitated by mecamylamine was also similar in wild-type and δ-opioid receptor knockout mice. In contrast, nicotine induced a conditioned place preference in wild-type animals that was abolished in knockout mice. Moreover, a lower percentage of acquisition of intravenous nicotine self-administration was observed in mice lacking δ-opioid receptors as well as in wild-type mice treated with the selective δ-opioid receptor antagonist naltrindole. Accordingly, in-vivo microdialysis studies revealed that the enhancement in dopamine extracellular levels induced by nicotine in the nucleus accumbens was reduced in mutant mice. In summary, the present results show that δ-opioid receptors are involved in the modulation of nicotine rewarding effects. However, this opioid receptor does not participate either in several acute effects of nicotine or in the development of tolerance and physical dependence induced by chronic nicotine administration.
dc.description.sponsorship This work was supported by the Spanish “Ministerio de Ciencia e Innovación”/n(#SAF2007-64062 and #SAF-2011-29864), the “Instituto de Salud Carlos III” grants/n#PI07/0559, #PI10/00316 and #RD06/001/001, the “Plan Nacional Sobre Drogas”/n(#2009/026), the Catalan Government (SGR2009-00131), and the ICREA Foundation/n(ICREA Academia Award-2008) to R.M. Partial support of FEDER funds is also acknowledged.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof Neuropsychopharmacology. 2012 Sep;37(10):2332-44
dc.rights © Nature Publishing Group. http://dx.doi.org/10.1038/npp.2012.88
dc.subject.other Animals -- Hàbits i conducta
dc.subject.other Drogues -- Efectes secundaris
dc.subject.other Nicotina -- Farmacologia
dc.subject.other Opiacis
dc.title Influence of δ-opioid receptors in the behavioral effects of nicotine
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/npp.2012.88
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2007-64062
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-29864
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

Compliant to Partaking