• Guidelines for FAIR sharing of preclinical safety and off-target pharmacology data

  Briggs, Katharine; Bosc, Nicolas; Camara, Tima; Diaz, Carlos; Drew, Phil; Drewe, William C.; Kors, Jan A.; Mulligen, Erik van; Pastor Maeso, Manuel; Pognan, François; Quintana, Jordi; Sarntivijai, Sirarat; Steger-Hartmann, Thomas (Spektrum Akademischer Verlag, 2021)

  Pre-competitive data sharing can offer the pharmaceutical industry significant benefits in terms of reducing the time and costs involved in getting a new drug to market through more informed testing strategies and knowledge ...
• SARC-F as a case-finding tool for sarcopenia according to the EWGSOP2. National validation and comparison with other diagnostic standards

  Piotrowicz, Karolina; Gluszewska, Anna; Czesak, Joanna; Fedyk-Lukasik, Malgorzata; Klimek, Ewa; Sánchez Rodríguez, Dolores; Skalska, Anna; Gryglewska, Barbara; Grodzicki, Tomasz; Gasowski, Jerzy (Springer, 2021)

  Background: Sarcopenia is a potentially reversible condition, which requires proper screening and diagnosis. Aims: To validate a Polish version of sarcopenia screening questionnaire (SARC-F), and assess its clinical ...
• SEOM clinical guideline for the management of immune-related adverse events in patients treated with immune checkpoint inhibitors (2019)

  Majem, Margarita; García-Martínez, E.; Martínez-García, Maria; Muñoz-Couselo, E.; Rodríguez-Abreu, D.; Alvarez, R.; Arance, A.; Berrocal, A.; de la Cruz-Merino, L.; López-Martín, J.A. (SpringerOpen, 2020)

  The use of immune checkpoint inhibitors has emerged as an effective treatment option for patients with several tumor types. By increasing the activity of the immune system, they can induce inflammatory side effects, which ...
• Multimorbidity patterns in chronic older patients, potentially inappropriate prescribing and adverse drug reactions: protocol of the multicentre prospective cohort study MoPIM

  Baré, Marisa; Herranz, Susana; Jordana, Rosa; Queralt Gorgas, Maria; Ortonobes, Sara; Sevilla, Daniel; de Jaime Gil, Elisabet; Ibarra, Olatz; Martín, Candelaria; MoPIM study group (BMJ Publishing Group, 2020)

  Introduction: Multimorbidity is a major challenge for current healthcare systems and professionals. From the different approaches that have been proposed to analyse this issue, the hypothesis of the existence of association ...
• Psoriasiform eruption secondary to PI3K-delta inhibitor: expanding the spectrum of psoriasiform paradoxical reactions?

  Pesqué, David; Sánchez González, Blanca; Gallardo Hernández, Fernando; Segura Tigell, Sonia; Pujol Vallverdú, Ramon Maria (Society for Publication of Acta Dermato-Venereologica, 2021)
• Extreme downregulation of chromosome Y and cancer risk in men

  Cáceres, Alejandro; Jene, Aina; Esko, Tõnu; Pérez Jurado, Luis Alberto; González, Juan Ramón (Oxford University Press, 2020)

  Background: Understanding the biological differences between sexes in cancer is essential for personalized treatment and prevention. We hypothesized that the extreme downregulation of chromosome Y gene expression (EDY) is ...
• Correlation between work impairment, scores of rhinitis severity and asthma using the MASK-air® App

  Bédard, Annabelle, 1986-; Antó i Boqué, Josep Maria; Garcia Aymerich, Judith; Basagaña Flores, Xavier; MASK study group (Wiley-Blackwell, 2020)

  Background: In allergic rhinitis, a relevant outcome providing information on the effectiveness of interventions is needed. In MASK-air (Mobile Airways Sentinel Network), a visual analogue scale (VAS) for work is used as ...
• Comparative effectiveness research in localized prostate cancer: a 10-year follow-up cohort study

  Garin Boronat, Olatz, 1979-; Suárez, José Francisco; Guedea, Ferrán; Pont Acuña, Àngels; Pardo Cladellas, Yolanda; Goñi, Alai; Mariño, Alfonso; Hervás, Asunción; Herruzo, Ismael; Cabrera Roldán, Patricia; Sancho-Pardo, Gemma; Ponce de León, Javier; Macías, Víctor; Gutiérrez, Cristina; Castells Esteve, Manel; Ferrer, Montserrat; Multicentric Spanish Group of Clinically Localized Prostate Cancer (Elsevier, 2021)

  Purpose: Long-term comparative effectiveness research on localized prostate cancer treatments is scarce, and evidence is lacking especially for brachytherapy. The aim of this study was to assess the long-term impact of the ...
• Specific IgA and CLA + T-Cell IL-17 response to streptococcus pyogenes in psoriasis

  de Jesús-Gil, Carmen; Sans-de San Nicolás, Lidia; Ruiz-Romeu, Ester; Ferran Farrés, Marta; Soria-Martinez, Laura; Chiriac, Anca; Celada, Antonio; Pujol Vallverdú, Ramon Maria; Santamaria-Babi, Luis F. (Elsevier, 2020)

  Streptococcus pyogenes tonsillar infection is well known to trigger and exacerbate psoriasis lesions in both guttate and plaque forms of the disease. Although mucosal and cutaneous tissues are closely involved in psoriasis ...
• Diagnóstico endoscópico de carcinoma pulmonar de célula pequeña y neoplasia folicular de tiroides

  Bellido, Salomé; Martín-Ontiyuelo, Clara; Pijuan Andujar, Lara; Puig de Dou, Jaume; Suárez-Piñera, Marina; Curull Serrano, Víctor; Sánchez Font, Albert (Elsevier, 2020)
• The eTRANSAFE project on translational safety assessment through integrative knowledge management: achievements and perspectives

  Pognan, François; Centeno, Emilio; Furlong, Laura I., 1971-; Guney, Emre; Mayer Pujadas, Miguel Ángel; Pastor Maeso, Manuel; Piñero González, Janet, 1977-; Ramírez Anguita, Juan Manuel; Ronzano, Francesco; Saüch Pitarch, Josep; Sanz, Ferran (MDPI, 2021)

  eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety ...
• Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach

  Carcereny, Enric; Fernández Nistal, Alonso; López, Araceli; Montoto, Carmen; Naves, Andrea; Segú Vergés, Cristina; Coma Camprodón, Mireia; Jorba, Guillem; Oliva Miguel, Baldomero; Mas, José Manuel (Impact Journals, 2021)

  Around 3-7% of patients with non-small cell lung cancer (NSCLC), which represent 85% of diagnosed lung cancers, have a rearrangement in the ALK gene that produces an abnormal activity of the ALK protein cell signaling ...
• Electron paramagnetic resonance gives evidence for the presence of type 1 gonadotropin-releasing hormone receptor (GnRH-R) in subdomains of lipid rafts

  Koklič, Tilen; Hrovat, Alenka; Guixà González, Ramon, 1978-; Rodríguez Espigares, Ismael, 1990-; Navio, Damaris; Frangež, Robert; Uršič, Matjaž; Kubale, Valentina; Plemenitaš, Ana; Selent, Jana; Šentjurc, Marjeta; Vrecl, Milka (MDPI, 2021)

  This study investigated the effect of type 1 gonadotropin releasing hormone receptor (GnRH-R) localization within lipid rafts on the properties of plasma membrane (PM) nanodomain structure. Confocal microscopy revealed ...
• Tuberculosis-HIV co-infection: progress and challenges after two decades of global antiretroviral treatment roll-out

  Letang Jiménez de Anta, Emilio Ángel; Ellis, Jayne; Naidoo, Kogieleum; Casas, Esther C.; Sánchez-Martínez, Francisca; Hassan-Moosa, Razia; Cresswell, Fiona; Miró, José María; García-Basteiro, Alberto L. (Elsevier, 2020)

  Despite wide antiretroviral scale-up during the past two decades resulting in declining new infections and mortality globally, HIV-associated tuberculosis remains as a major public health concern. Tuberculosis is the leading ...
• Clinical and economic burden of community-onset multidrug-resistant infections requiring hospitalization

  López Montesinos, Inmaculada; Domínguez-Guasch, A.; Gómez-Zorrilla, Silvia; Duran Jordà, Xavier, 1974-; Siverio-Parès, Ana; Arenas-Miras, María Del Mar; Montero, Maria Milagro; Sorli Redó, M. Luisa; Grau Cerrato, Santiago; Horcajada Gallego, Juan Pablo (Elsevier, 2020)

  Objectives: To analyze the clinical and economic burden of community-acquired (CA) or community-onset healthcare-associated (COHCA) multidrug-resistant (MDR) infections requiring hospitalization. Methods: Case-control ...
• Asma leve y exacerbaciones de riesgo vital: ¿es hora de que demos un paso adelante?

  González-García, José Gregorio; Chalela Rengifo, Roberto José, 1985-; Carballo Martínez, Núria; Ausín Herrero, Pilar, 1974- (Elsevier, 2020)
• Impact of a community contraceptive counselling intervention on adolescent fertility rates: a quasi-experimental study

  Díez, Elia; López, María J.; Pérez, Glòria; García Subirats, Irene, 1982-; Nebot, Laia; Carreras Collado, Ramón; Villalbí, Joan R. (BioMed Central, 2020)

  Background: From 2000 to 2008, in urban areas in Spain, adolescent fertility and abortion rates underwent unprecedented increases, consecutive to intensive immigration from developing countries. To address unmet needs for ...
• Cannabis use induces distinctive proteomic alterations in olfactory neuroepithelial cells of schizophrenia patients

  Barrera Conde, Marta; Ausín, Karina; Lachén Montes, Mercedes; Fernández Irigoyen, Joaquín; Galindo Guarín, Liliana; Cuenca Royo, Aida Ma, 1981-; Fernández Avilés, Cristina; Pérez, Victor; Torre Fornell, Rafael de la; Santamaría, Enrique; Robledo, Patricia, 1958- (MDPI, 2021)

  A close epidemiological link has been reported between cannabis use and schizophrenia (SCZ). However, biochemical markers in living humans related to the impact of cannabis in this disease are still missing. Olfactory ...
• Complete genomic characterization of a new KLRC2 allele, NKG2C*03

  Asenjo, Judit; Muntasell i Castellví, Aura, 1972-; López-Botet, M. (Miguel); Moraru, Manuela; Vilches, Carlos (Wiley, 2021)
• B cells and tertiary lymphoid structures influence survival in lung cancer patients with resectable tumors

  Tang, Jun; Ramis Cabrer, Daniel, 1993-; Curull Serrano, Víctor; Wang, Xuejie; Mateu Jiménez, Mercè, 1990-; Pijuan Andujar, Lara; Duran, Xavier; Qin, Liyun; Rodríguez-Fuster, Alberto; Aguiló Espases, Rafael; Barreiro Portela, Esther (MDPI, 2020)

  Immune profile of B and T cells and tertiary lymphoid structures (TLSs) may differ in tumors of lung cancer (LC) patients with/without chronic obstructive pulmonary disease (COPD), and may also influence patient survival. ...

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