• Estándares SEA 2022 para el control global del riesgo cardiovascular

  Mostaza, José María; Pedro-Botet, Juan Carlos; Vila, Lluis (Elsevier, 2022)

  La Sociedad Española de Arteriosclerosis tiene entre sus objetivos contribuir al mayor y mejor conocimiento de la enfermedad vascular, su prevención y su tratamiento. Es de sobra conocido que las enfermedades cardiovasculares ...
• Screening for prognostic microRNAs associated with treatment failure in diffuse large B cell lymphoma

  Bento, Leyre; Vögler, Oliver; Sas-Barbeito, Adriana; Muncunill, Josep; Ros, Teresa; Martínez, Jordi; Quintero-Duarte, Adriana; Ramos, Rafel; Asensio, Víctor Jose; Fernández Rodríguez, M. Concepción; Salar Silvestre, Antonio; Navarro, Alfons; Del Campo, Raquel; Ibarra, Javier; Alemany, Regina; Gutiérrez, Antonio (MDPI, 2022)

  Diffuse large B cell lymphoma (DLBCL) treatment with R-CHOP regimen produces 5-year progression-free survival and overall survival of around 60-70%. Our objective was to discover prognostic biomarkers allowing early detection ...
• Recent advances in the genetic of MALT lymphomas

  Rodríguez-Sevilla, Juan José; Salar Silvestre, Antonio (MDPI, 2021)

  Mucosa-associated lymphoid tissue (MALT) lymphomas are a diverse group of lymphoid neoplasms with B-cell origin, occurring in adult patients and usually having an indolent clinical behavior. These lymphomas may arise in ...
• Peptides against low density lipoprotein (LDL) aggregation inhibit intracellular cholesteryl ester loading and proliferation of pancreatic tumor cells

  Benitez-Amaro, Aleyda; Martínez Bosch, Neus; Manero Rupérez, Noemí; Claudi, Lene; La Chica Lhoëst, Maria Teresa; Soler, Marta; Ros Blanco, Lia; Navarro Medrano, Pilar; Llorente-Cortés, Vicenta (MDPI, 2022)

  Dyslipidemia, metabolic disorders and/or obesity are postulated as risk factors for pancreatic ductal adenocarcinoma (PDAC). The majority of patients with these metabolic alterations have low density lipoproteins (LDLs) ...
• Identification of Lynch syndrome carriers among patients with small bowel adenocarcinoma

  Sánchez, Ariadna; Hernandez, Goretti; Iglesias Coma, Mar; Moreira, Leticia (MDPI, 2021)

  Background: Small bowel adenocarcinoma (SBA) is a rare disease which can be associated with Lynch syndrome (LS). LS tumors are characterized by the presence of microsatellite instability (MSI) and/or the loss of mismatch ...
• Hepatocellular carcinoma: Molecular pathogenesis and therapeutic advances

  Cucarull-Martínez, Blanca; Tutusaus, Anna; Rider, Patricia; Hernáez-Alsina, Tania; Cuño, Carlos; García de Frutos, Pablo; Colell, Anna; Marí, Montserrat; Morales, Albert (MDPI, 2022)

  Hepatocellular carcinoma (HCC), the most common form of liver cancer, continues to be a serious medical problem with poor prognosis, without major therapeutic improvement for years and increasing incidence. Fortunately, ...
• Epithelial-to-mesenchymal transition mediates resistance to maintenance therapy with vinflunine in advanced urothelial cell carcinoma

  Font, Albert; Ruiz de Porras, Vicenç; Valderrama, Begoña P.; Ramirez, Jose Luis; Nonell Mazelón, Lara; Virizuela, José Antonio; Anido, Urbano; González-Del-Alba, Aránzazu; Lainez, Nuria; Llorente, Maria Del Mar; Jiménez, Natalia; Mellado, Begoña; García-Donas, Jesús; Bellmunt Molins, Joaquim, 1959- (MDPI, 2021)

  In the phase II MAJA trial, maintenance therapy with vinflunine resulted in longer progression-free survival compared to best supportive care in advanced urothelial cell carcinoma (aUCC) patients who did not progress after ...
• Real-world analysis of main clinical outcomes in patients with polycythemia vera treated with ruxolitinib or best available therapy after developing resistance/intolerance to hydroxyurea

  Alvarez-Larrán, Alberto; Bellosillo Paricio, Beatriz; Pereira, Arturo (Wiley, 2022)

  Background: Ruxolitinib is approved for patients with polycythemia vera (PV) who are resistant/intolerant to hydroxyurea, but its impact on preventing thrombosis or disease-progression is unknown. Methods: A retrospective, ...
• Sex-specific lesion pattern of functional outcomes after stroke

  Bonkhoff, Anna K.; Jiménez-Conde, Jordi; Roquer, Jaume; The International Stroke Genetics Consortium (ISGC) (Oxford University Press, 2022)

  Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinically relevant sex differences in the underlying causes, presentations and outcomes of acute ...
• A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials

  Lemaréchal, Jean-Didier; Rocamora Zúñiga, Rodrigo Alberto; F-TRACT consortium (Oxford University Press, 2022)

  Epilepsy presurgical investigation may include focal intracortical single-pulse electrical stimulations with depth electrodes, which induce cortico-cortical evoked potentials at distant sites because of white matter ...
• On the association between Chiari malformation type 1, bone mineral density and bone related genes

  Martínez-Gil, Núria; Mellibovsky, Leonardo; Manzano-López González, Demián; Patiño, Juan David; Cozar, Mónica; Rabionet, Raquel; Grinberg, Daniel; Balcells, Susana (Elsevier, 2022)

  Background: Chiari malformation type 1 (C1M) is a neurological disease characterized by herniation of the cerebellar tonsils below the foramen magnum. Cranial bone constriction is suspected to be its main cause. To date, ...
• Factors associated with recruitment success in the phase 2a study of aztreonam-avibactam development programme: a descriptive qualitative analysis among sites in Spain

  Jimenez-Rodriguez, Rosa M.; Martín-Gutiérrez, Guillermo; Jiménez-Jorge, Silvia; Rosso-Fernández, Clara M.; Tallón-Aguilar, Luis; Roca-Oporto, Cristina; Padillo, Javier; Luckey, Alison; Cano, Angela; López-Ruiz, José; Gómez-Zorrilla, Silvia; Bonnín-Pascual, Jaime; Boix Palop, Lucía; Montejo, José Miguel; Torre-Cisneros, Julian; Cisneros, José M. (BMJ Publishing Group, 2022)

  Objective: Successful clinical trials are subject to recruitment. Recently, the REJUVENATE trial, a prospective phase 2a open-label, single-arm interventional clinical trial conducted within the Innovative Medicines ...
• Characteristics and outcomes of patients with COVID-19 with and without prevalent hypertension: a multinational cohort study

  Reyes, Carlen; Sorlí, Luisa; López Montesinos, Inmaculada; Duarte Salles, Talita, 1985- (BMJ Publishing Group, 2021)

  Objective: To characterise patients with and without prevalent hypertension and COVID-19 and to assess adverse outcomes in both inpatients and outpatients. Design and setting: This is a retrospective cohort study using 15 ...
• A new tool to screen patients with severe obstructive sleep apnea in the primary care setting: a prospective multicenter study

  Peñacoba, Patricia; Llauger, M. Antònia; Fortuna, Ana M.; Flor, Xavier; Sampol, Gabriel; Pedro Pijoan, Anna María; Grau Sanmartí, Núria, 1974-; Santiveri, Carme; Juvanteny, Joan; Aoiz, José Ignacio; Bayó, Joan; Lloberes, Patricia; Mayos, Mercè; PASHOS Working Group (BioMed Central, 2022)

  Background: The coordination between different levels of care is essential for the management of obstructive sleep apnea (OSA). The objective of this multicenter project was to develop a screening model for OSA in the ...
• Increasing emergency department admissions for chemsex-related intoxications in Barcelona, Spain, among people living with HIV: an observational study from 2018 to 2020

  Vallecillo, Gabriel; Losada, Alejandra; Inciarte, Alexy; Jiwei, Chen; Monterde, Albert; Salgado, Emilio; Doi, Adriana Laura; Monclus, Esther; Perelló, Rafael (BioMed Central, 2022)

  Background: Chemsex is a novel phenomenon referring to the use of drugs, including crystal methamphetamine, gammahydroxybutyric acid (GHB)/gamma-butyrolactone (GABA) and mephedrone, to facilitate, enhance, and prolong the ...
• The feasibility and reliability of measuring forearm muscle thickness by ultrasound in a geriatric inpatient setting: a cross-sectional pilot study

  Meza Valderrama, Delky; Sánchez-Rodríguez, Dolores; Perkisas, Stany; Duran Jordà, Xavier, 1974-; Bastijns, Sophie; Dávalos Yerovi, Vanesa; Da Costa, Elizabeth; Marco Navarro, Ester (BioMed Central, 2022)

  Background: Given the potential benefits of introducing ultrasound in the clinical assessment of muscle disorders, this study aimed to assess the feasibility and reliability of measuring forearm muscle thickness by ultrasound ...
• Factors associated to potentially inappropriate prescribing in older patients according to STOPP/START criteria: MoPIM multicentre cohort study

  Baré, Marisa; Lleal, Marina; Ortonobes, Sara; Queralt Gorgas, Maria; Sevilla-Sánchez, Daniel; Carballo Martínez, Núria; de Jaime Gil, Elisabet; Herranz, Susana; MoPIM study group (BioMed Central, 2022)

  Objectives: The objectives of the present analyses are to estimate the frequency of potentially inappropriate prescribing (PIP) at admission according to STOPP/START criteria version 2 in older patients hospitalised due ...
• 1L NER1006 can improve rates of adequate and high-quality bowel cleansing in the right colon: a post hoc analysis of two randomised clinical trials

  Manning, Jonathan R.; Halonen, Juha; Cheriyamkunnel, Sandra José; Álvarez-González, Marco Antonio (BioMed Central, 2022)

  Background: The right colon is difficult to cleanse compared with other colon segments. This post hoc analysis of two randomised clinical trials (MORA and NOCT) examined whether 1L polyethylene glycol (PEG) NER1006 and two ...
• Sézary syndrome patient-derived models allow drug selection for personalized therapy

  Gallardo Hernández, Fernando; Andrades, Evelyn; Iglesias, Arnau; González, Jessica; Solé, Laura; Guillén, Yolanda; Blanco Ares, Gonzalo, 1989-; Colomo Saperas, Luis Alberto; Gimeno, Eva; Conde Estévez, David; Rodríguez, Eva; Bielsa-Marsol, Isabel; Iglesias Coma, Mar; Bellosillo Paricio, Beatriz; Pujol Vallverdú, Ramon Maria; Regueiro, José R.; Bigas Salvans, Anna; Espinosa Blay, Lluís (American Society of Hematology, 2022)

  Current therapeutic approaches for Sézary syndrome (SS) do not achieve a significant improvement in long-term survival of patients, and they are mainly focused on reducing blood tumor burden to improve quality of life. ...
• Impact of non-persistence on healthcare resource utilization and costs in patients with immune-mediated rheumatic diseases initiating subcutaneous TNF-alpha anhibitors: a before-and-after study

  Carballo Martínez, Núria; García-Alzórriz, Enric; Ferrández, Olivia; Navarrete Rouco, Maria Eugenia; Duran Jordà, Xavier, 1974-; Pérez-García, Carolina; Monfort Faure, Jorge; Cots Reguant, Francesc; Grau Cerrato, Santiago (Frontiers, 2021)

  Rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis are chronic progressive immune-mediated rheumatic diseases (IMRD) that can cause a progressive disability and joint deformation and thus can impact in ...

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