Articles (Center for Genomic Regulation (CRG))

 

Recent Submissions

  • Akinci, Muge; Peña-Gómez, Cleofé; Operto, Grégory; Fuentes-Julian, Sherezade; Deulofeu, Carme; Sánchez Benavides, Gonzalo; Milà Alomà, Marta; Grau-Rivera, Oriol; Gramunt Fombuena, Nina; Navarro i Cuartiellas, Arcadi, 1969-; Minguillón, Carolina; Fauria, Karine; Suridjan, Ivonne; Kollmorgen, Gwendlyn; Bayfield, Anna; Blennow, Kaj; Zetterberg, Henrik; Molinuevo, José Luis; Suárez-Calvet, Marc; Gispert López, Juan Domingo; Arenaza-Urquijo, Eider M.; ALFA Study (Lippincott Williams & Wilkins, 2022)
    Background and objectives: Increased anxious-depressive symptomatology is observed in the preclinical stage of Alzheimer disease (AD), which may accelerate disease progression. We investigated whether β-amyloid, cortical ...
  • Gopalakrishnan, Shyam; Juan, David; Gelabert Xirinachs, Pere, 1991-; Marquès i Bonet, Tomàs, 1975-; Lalueza Fox, Carles, 1965-; Gilbert, M Thomas (Elsevier, 2022)
    Human populations have been shaped by catastrophes that may have left long-lasting signatures in their genomes. One notable example is the second plague pandemic that entered Europe in ca. 1,347 CE and repeatedly returned ...
  • Prados de la Torre, Esther; Obando, Ignacio; Vidal, Marta; Felipe, Beatriz de; Aguilar, Ruth; Izquierdo, Luis; Carolis, Carlo; Olbrich, Peter; Capilla-Miranda, Ana; Serra, Pau; Santamaria, Pere; Blanco-Lobo, Pilar; Moncunill, Gemma; Rodríguez-Ortega, Manuel J.; Dobaño, Carlota (MDPI, 2022)
    SARS-CoV-2 infection has become a global health problem specially exacerbated with the continuous appearance of new variants. Healthcare workers (HCW) have been one of the most affected sectors. Children have also been ...
  • Martínez Hernández, Francisco; Fornas Carreño, Oscar; Martínez García, Manuel (MDPI, 2022)
    Single-virus genomics (SVGs) has been successfully applied to ocean surface samples allowing the discovery of widespread dominant viruses overlooked for years by metagenomics, such as the uncultured virus vSAG 37-F6 infecting ...
  • Rocafort, Muntsa; Henares, Desiree; Brotons, Pedro; Launes, Cristian; Fernandez de Sevilla, Mariona; Fumadó, Victoria; Barrabeig, Irene; Arias, Sara; Redin, Alba; Ponomarenko, Julia; Mele, Maria; Millat-Martínez, Pere; Claverol, Joana; Balanza, Núria; Mira, Alex; Garcia-Garcia, Juan Jose; Bassat, Quique; Jordan, Iolanda; Muñoz-Almagro, Carmen (MDPI, 2022)
    The increased incidence of COVID-19 cases and deaths in Spain in March 2020 led to the declaration by the Spanish government of a state of emergency imposing strict confinement measures on the population. The objective of ...
  • Plana-Carmona, Marcos; Stik, Grégoire; Bulteau, Romain; Segura-Morales, Carolina; Alcázar, Noelia; Wyatt, Christopher Douglas Robert, 1988-; Klonizakis, Antonios; Andrés Aguayo, Luisa de; Gasnier, Maxime; Tian, Tian V.; Torcal Garcia, Guillem, 1991-; Vila-Casadesús, Maria; Plachta, Nicolas; Serrano, Manuel; Francesconi, Mirko; Graf, T. (Thomas) (Elsevier, 2022)
    IL-6 has been shown to be required for somatic cell reprogramming into induced pluripotent stem cells (iPSCs). However, how Il6 expression is regulated and whether it plays a role during embryo development remains unknown. ...
  • Barsby, Tom; Ibrahim, Hazem; Lithovius, Väinö; Montaser, Hossam; Balboa, Diego; Vähäkangas, Eliisa; Chandra, Vikash; Saarimäki-Vire, Jonna; Otonkoski, Timo (Elsevier, 2022)
    We present here a robust and reliable protocol by which to differentiate pancreatic islet-like aggregates (SC-islets) from human pluripotent stem cells. The 7-stage protocol mimics developmental patterning factors that ...
  • Hernandez, Ainhoa; Muñoz-Mármol, Ana M.; Esteve-Codina, Anna; Alameda Quitllet, Francisco; Carrato, Cristina; Pineda, Estela; Arpí Llucià, Oriol; Martinez-García, Maria; Mallo, Mar; Gut, Marta; Barco Berrón, Sonia del; Gallego, Oscar; Dabad, Marc; Mesia, Carlos; Bellosillo Paricio, Beatriz; Domenech, Marta; Vidal, Noemí; Aldecoa, Iban; Iglesia, Nuria de la; Balana, Carmen (Nature Research, 2022)
    RNA-Sequencing (RNA-Seq) can identify gene fusions in tumors, but not all these fusions have functional consequences. Using multiple data bases, we have performed an in silico analysis of fusions detected by RNA-Seq in ...
  • Castro-Arnau, Júlia; Chauvigné, François; Gómez-Garrido, Jèssica; Esteve-Codina, Anna; Dabad, Marc; Alioto, Tyler; Finn, Roderick Nigel; Cerdà, Joan (Nature Research, 2022)
    In non-mammalian vertebrates, the molecular mechanisms involved in the transformation of haploid germ cells (HGCs) into spermatozoa (spermiogenesis) are largely unknown. Here, we investigated this process in the marine ...
  • Guegan, Fabien; Rajan, K. Shanmugha; Bento, Fábio; Pinto-Neves, Daniel; Sequeira, Mariana; Gumińska, Natalia; Mroczek, Seweryn; Dziembowski, Andrzej; Cohen-Chalamish, Smadar; Doniger, Tirza; Galili, Beathrice; Estévez, Antonio M.; Notredame, Cedric; Michaeli, Shulamit; Figueiredo, Luisa M. (American Association for the Advancement of Science (AAAS), 2022)
    The parasite Trypanosoma brucei causes African sleeping sickness that is fatal to patients if untreated. Parasite differentiation from a replicative slender form into a quiescent stumpy form promotes host survival and ...
  • Muñoz-Gil, Gorka; Romero-Aristizabal, Catalina; Mateos, Nicolas; Campelo, Felix; De Llobet, Lara Isabel; Beato, Miguel; Lewenstein, Maciej; Garcia-Parajo, Maria F.; Torreno-Pina, Juan A. (National Academy of Sciences, 2022)
    Liquid-liquid phase separation (LLPS) is emerging as a key physical principle for biological organization inside living cells, forming condensates that play important regulatory roles. Inside living nuclei, transcription ...
  • Henkin, Gil; Chew, Wei-Xiang; Nédélec, François; Surrey, Thomas (National Academy of Sciences, 2022)
    During cell division, cross-linking motors determine the architecture of the spindle, a dynamic microtubule network that segregates the chromosomes in eukaryotes. It is unclear how motors with opposite directionality ...
  • Bovolenta, Elena R.; García-Cuesta, Eva M.; Horndler, Lydia; Ponomarenko, Julia; Schamel, Wolfgang W.; Mellado, Mario; Castro, Mario; Abia, David; van Santen, Hisse M. (National Academy of Sciences, 2022)
    Signaling via the T cell receptor (TCR) is critical during the development, maintenance, and activation of T cells. Quantitative aspects of TCR signaling have an important role during positive and negative selection, lineage ...
  • Miró Pina, Verónica; Nava-Trejo, Julio; Tóbiás, Andras; Nzabarushimana, Etienne; González-Casanova, Adrián; González-Casanova, Inés (Public Library of Science (PLoS), 2022)
    Preventive and modeling approaches to address the COVID-19 pandemic have been primarily based on the age or occupation, and often disregard the importance of heterogeneity in population contact structure and individual ...
  • Palmer, William H.; Telford, Marco, 1984-; Navarro i Cuartiellas, Arcadi, 1969-; Santpere Baró, Gabriel, 1981-; Norman, Paul J. (National Academy of Sciences, 2022)
    Herpesviruses are ubiquitous, genetically diverse DNA viruses, with long-term presence in humans associated with infrequent but significant pathology. Human leukocyte antigen (HLA) class I presents intracellularly derived ...
  • Neumann, Alexander; Vilor Tejedor, Natàlia, 1988-; Alemany, Silvia; Sunyer Deu, Jordi; Tiemeier, Henning (Public Library of Science (PLoS), 2022)
    Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in ...
  • Mestre-Farràs, Neus; Guerrero Jijon, Santiago Xavier; Bley, Nadine; Rivero, Ezequiel; Coll, Olga; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Indacochea Cusirramos, Alberto; Casillas-Serra, Carlos; Järvelin, Aino I.; Oliva Miguel, Baldomero; Castello, Alfredo; Hüttelmaier, Stefan; Gebauer, Fátima (Oxford University Press, 2022)
    RNA-binding proteins (RBPs) have been relatively overlooked in cancer research despite their contribution to virtually every cancer hallmark. Here, we use RNA interactome capture (RIC) to characterize the melanoma RBPome ...
  • Nadeu, Ferran; Massoni-Badosa, Ramon; Ruiz Gil, Sara; Marchese, Domenica, 1986-; López Bigas, Núria; Gut, Ivo Glynne; Heyn, Holger; Campo, Elias (Nature Research, 2022)
    Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia (CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The mechanisms driving RT remain largely unknown. ...
  • Carter, Jason A.; Strömich, Léonie; Peacey, Matthew; Chapin, Sarah R.; Velten, Lars; Steinmetz, Lars M.; Brors, Benedikt; Pinto, Sheena; Meyer, Hannah V. (Nature Research, 2022)
    The induction of central T cell tolerance in the thymus depends on the presentation of peripheral self-epitopes by medullary thymic epithelial cells (mTECs). This promiscuous gene expression (pGE) drives mTEC transcriptomic ...
  • Vali-Pour, Mischan; Lehner, Ben, 1978-; Supek, Fran (Nature Research, 2022)
    Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types of somatic mutation vary across individuals, but relatively few inherited influences on mutation processes ...

View more