Articles (Center for Genomic Regulation (CRG))

 

Recent Submissions

  • Rovira Clusellas, Meritxell; Atla, Goutham; Maestro, Miguel Ángel; Grau, Vanessa; García-Hurtado, Javier; Maqueda, Maria; Mosquera, Jose Luis; Yamada, Yasuhiro; Kerr-Conte, Julie; Pattou, Francois; Ferrer, Jorge (Cold Spring Harbor Laboratory Press (CSHL Press), 2021)
    Multiple transcription factors have been shown to promote pancreatic β-cell differentiation, yet much less is known about negative regulators. Earlier epigenomic studies suggested that the transcriptional repressor REST ...
  • Martínez-Torró, Carlos; Torres-Puig, Sergi; Marcos-Silva, Marina; Huguet-Ramón, Marta; Muñoz-Navarro, Carmen; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982-; Querol, Enrique; Piñol, Jaume; Pich, Oscar Q. (Frontiers Media, 2021)
    It is well-established that FtsZ drives peptidoglycan synthesis at the division site in walled bacteria. However, the function and conservation of FtsZ in wall-less prokaryotes such as mycoplasmas are less clear. In the ...
  • Tejedor Vaquero, Sonia, 1988-; Campos Mata, Leire de, 1991-; Ramada Rodilla, José María, 1961-; Díaz, Pilar; Navarro-Barriuso, Juan; Ribas-Llauradó, Clara; Rodrigo Melero, Natalia; Carolis, Carlo; Cerutti, Andrea, 1965-; Gimeno Martínez, Ramón; Magri, Giuliana, 1978- (Frontiers Media, 2021)
    mRNA-based vaccines effectively induce protective neutralizing antibodies against SARS-CoV-2, the etiological agent of COVID-19. Yet, the kinetics and compositional patterns of vaccine-induced antibody responses to the ...
  • Papadopoulou, Eleni, 1985-; Basagaña Flores, Xavier; Casas Sanahuja, Maribel; Fossati, Serena; Maitre, Léa; Sabidó Aguadé, Eduard, 1981-; Borràs, Eva; Urquiza, José M.; Vrijheid, Martine; Chatzi, Leda (Elsevier, 2021)
    Developing children are particularly vulnerable to the effects of exposure to per- and polyfluoroalkyl substances (PFAS), a group of endocrine disrupting chemicals. We hypothesized that early life exposure to PFASs is ...
  • Marruecos, Laura; Bertran, Joan; Álvarez-Villanueva, Daniel; Mulero, María Carmen; Guillén, Yolanda; Palma, Luis G.; Floor, Martin; Vert, Anna; Arce-Gallego, Sara; Pecharroman, Irene; Batlle Masó, Laura, 1993-; Villà i Freixa, Jordi; Ghosh, Gourisankar; Bigas Salvans, Anna; Espinosa Blay, Lluís (Wiley, 2021)
    IκBs exert principal functions as cytoplasmic inhibitors of NF-kB transcription factors. Additional roles for IκB homologues have been described, including chromatin association and transcriptional regulation. Phosphorylated ...
  • White, Anna E.; Dios Martínez, Toni de, 1994-; Carrión, Pablo; Bonora, Gian Luca; Llovera, Laia; Cilli, Elisabetta; Lizano González, Esther, 1974-; Khabdulina, Maral K.; Tleugabulov, Daniyar T.; Olalde Marquínez, Íñigo, 1987-; Marquès i Bonet, Tomàs, 1975-; Balloux, François; Pettener, Davide; van Dorp, Lucy; Luiselli, Donata; Lalueza Fox, Carles, 1965- (MDPI, 2021)
    The Asian Central Steppe, consisting of current-day Kazakhstan and Russia, has acted as a highway for major migrations throughout history. Therefore, describing the genetic composition of past populations in Central Asia ...
  • Dhandapani, Laasya; Salzer, Marion C.; Duran, Juan M.; Zaffagnini, Gabriele; De Guirior, Cristian; Martínez-Zamora, Maria Angeles; Böke, Elvan (Company of Biologists, 2022)
    Oocytes spend the majority of their lifetime in a primordial state. The cellular and molecular biology of primordial oocytes is largely unexplored; yet, it is necessary to study them to understand the mechanisms through ...
  • Raote, Ishier; Saxena, Sonashree; Campelo, Felix; Malhotra, Vivek (Elsevier, 2021)
    TANGO1 protein facilitates the endoplasmic reticulum (ER) export of large cargoes that cannot be accommodated in 60 nm transport vesicles. It assembles into a ring in the plane of the ER membrane to create a distinct domain. ...
  • Alemany, Silvia; Vilor Tejedor, Natàlia, 1988-; Milà Alomà, Marta; Suárez-Calvet, Marc; Salvadó, Gemma; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Grau-Rivera, Oriol; Minguillón, Carolina; Fauria, Karine; Domingo Gispert, Juan; Gascon Merlos, Mireia, 1984-; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi; ALFA Study (Elsevier, 2021)
    Background: Air quality contributes to incidence of Alzheimer's disease (AD) although the underlying neurobiological mechanisms are unclear. This study was aimed to examine the association between air pollution and ...
  • Garrison, Helen; Agostinho, Marta; Alvarez, Laura; Bekaert, Sofia; Bengtsson, Luiza; Broglio, Elisabetta; Couso, Digna; Araújo Gomes, Raquel; Ingram, Zoe; Martínez, Emma; Mena, Ana Lúcia; Nickel, Dörthe; Norman, Michael; Pinheiro, Inês; Solís-Mateos, Marta; Bertero, Michela G. (EMBO Press, 2021)
    Open Science calls for transparent science and involvement of various stakeholders. Here are examples of and advice for meaningful stakeholder engagement.
  • Ribera, Jordi; Portolés, Irene; Córdova-Jover, Bernat; Rodríguez-Vita, Juan; Casals, Gregori; Gónzalez-de la Presa, Bernardino; Graupera, Mariona; Solsona-Vilarrasa, Estel; Garcia-Ruiz, Carmen; Fernández-Checa, José C.; Soria, Guadalupe; Tudela, Raúl; Esteve-Codina, Anna; Espadas, Guadalupe; Sabidó Aguadé, Eduard, 1981-; Jiménez, Wladimiro; Sessa, William C.; Morales-Ruiz, Manuel (Nature Research, 2021)
    DHX15 is a downstream substrate for Akt1, which is involved in key cellular processes affecting vascular biology. Here, we explored the vascular regulatory function of DHX15. Homozygous DHX15 gene deficiency was lethal in ...
  • Campos Mata, Leire de, 1991-; Tejedor Vaquero, Sonia, 1988-; Tachó-Piñot, Roser; Piñero González, Janet, 1977-; Grasset, Emilie K.; Arrieta Aldea, Itziar; Rodrigo Melero, Natalia; Carolis, Carlo; Horcajada Gallego, Juan Pablo; Cerutti, Andrea, 1965-; Villar García, Judit; Magri, Giuliana, 1978- (Wiley Open Access, 2021)
    Objectives: SARS-CoV-2 infection induces virus-reactive memory B cells expressing unmutated antibodies, which hints at their emergence from naïve B cells. Yet, the dynamics of virus-specific naïve B cells and their impact ...
  • Alonso, Lorena; Ferrer, Jorge; Torrents, David (Elsevier, 2021)
    Genome-wide association studies (GWASs) identified hundreds of signals associated with type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have created the translational human pancreatic ...
  • Bonet, Jose; Chen, Mandi; Dabad, Marc; Heath, Simon; Gonzalez-Perez, Abel; López Bigas, Núria; Lagergren, Jens (Oxford University Press, 2021)
    Motivation: DNA Methylation plays a key role in a variety of biological processes. Recently, Nanopore long-read sequencing has enabled direct detection of these modifications. As a consequence, a range of computational ...
  • Chang, Jia-Ming, 1978-; Floden, Evan Wade; Herrero, Javier; Gascuel, Olivier; Di Tommaso, Paolo; Notredame, Cedric (Oxford University Press, 2019)
    Motivation: Most evolutionary analyses are based on pre-estimated multiple sequence alignment. Wong et al. established the existence of an uncertainty induced by multiple sequence alignment when reconstructing phylogenies. ...
  • Díaz-Rodríguez, Martín; Lithgow-Serrano, Oscar; Guadarrama-García, Francisco; Tierrafría, Víctor H.; Gama-Castro, Socorro; Solano-Lira, Hilda; Salgado, Heladia; Rinaldi, Fabio; Méndez-Cruz, Carlos-Francisco; Collado Vides, Pedro Julio (Elsevier, 2021)
    The number of published papers in biomedical research makes it rather impossible for a researcher to keep up to date. This is where manually curated databases contribute facilitating the access to knowledge. However, the ...
  • Borràs, Eva; Pastor, Olga; Sabidó Aguadé, Eduard, 1981- (American Chemical Society (ACS), 2021)
    The need for a better understanding of cellular heterogeneity has pushed mass spectrometry technologies to the analysis of single-cell and single-cell-type proteomes, although several challenges still limit their widespread ...
  • Gangfuß, Andrea; Lochmüller, Hanns; Töpf, Ana; O'Hehir, Emily; Horvath, Rita; Kölbel, Heike; Schweiger, Bernd; Schara-Schmidt, Ulrike; Roos, Andreas (Wiley, 2022)
    CSDE1 encodes the cytoplasmic cold shock domain-containing protein E1 (CSDE1), which is highly conserved across species and functions as an RNA-binding protein involved in translationally coupled mRNA turnover. CSDE1 ...
  • Farabella, Irene; Di Stefano, Marco; Soler-Vila, Paula; Marti Marimon, Maria; Marti-Renom, Marc A. (Nature Research, 2021)
    An increasing number of long noncoding RNAs (lncRNAs) have been proposed to act as nuclear organization factors during interphase. Direct RNA-DNA interactions can be achieved by the formation of triplex helix structures ...
  • Ahmadi, Amirhossein; Gispert López, Juan Domingo; Navarro i Cuartiellas, Arcadi, 1969-; Vilor Tejedor, Natàlia, 1988-; Sadeghi, Iman (Elsevier, 2021)
    In recent decades, our understanding of the molecular changes involved in neurodegenerative diseases has been transformed. Single-cell RNA sequencing and single-nucleus RNA sequencing technologies have been applied to ...

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