Articles (Center for Genomic Regulation (CRG))

 

Recent Submissions

  • Aguilera, Cinthia; Gabau, Elisabeth; Ramirez-Mallafré, Ariadna; Brun i Gasca, Carme; Dominguez-Carral, Jana; Delgadillo, Veronica; Laurie, Steven, 1973-; Derdak, Sophia; Padilla, Natàlia; Cruz, Xavier de la; Capdevila, Núria; Spataro, Nino, 1984-; Baena, Neus; Guitart, Miriam; Ruiz, Anna (Public Library of Science (PLoS), 2021)
    Angelman syndrome (AS) is a neurogenetic disorder characterized by severe developmental delay with absence of speech, happy disposition, frequent laughter, hyperactivity, stereotypies, ataxia and seizures with specific EEG ...
  • Milà Alomà, Marta; Brinkmalm, Ann; Ashton, Nicholas J.; Kvartsberg, Hlin; Shekari, Mahnaz; Operto, Grégory; Salvadó, Gemma; Falcon, Carles; Domingo Gispert, Juan; Vilor Tejedor, Natàlia, 1988-; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Sala Vila, Aleix; Sanchez-Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Zetterberg, Henrik; Molinuevo, José Luis; Blennow, Kaj; Suárez-Calvet, Marc; ALFA Study (Lippincott Williams & Wilkins, 2021)
    Background and objectives: To determine whether CSF synaptic biomarkers are altered in the early preclinical stage of the Alzheimer continuum and associated with Alzheimer disease (AD) risk factors, primary pathology, and ...
  • Garrido, Victoria; Piñero-Lambea, Carlos; Rodriguez-Arce, Irene; Paetzold, Bernhard, 1981-; Ferrar, Tony; Weber, Marc; Garcia Ramallo, Eva; Gallo López, Carolina, 1984-; Collantes, María; Peñuelas, Iván; Serrano Pubull, Luis, 1982-; Grilló, María-Jesús; Lluch-Senar, Maria 1982- (Wiley Open Access, 2021)
    Bacteria present a promising delivery system for treating human diseases. Here, we engineered the genome-reduced human lung pathogen Mycoplasma pneumoniae as a live biotherapeutic to treat biofilm-associated bacterial ...
  • Kubiak-Szymendera, Monika; Pryszcz, Leszek Piotr, 1985-; Biatas, Wojciech; Celinska, Ewelina (MDPI, 2021)
  • Asthana, Jayant; Cade, Nicholas Ian; Normanno, Davide; Lim, Wei Ming; Surrey, Thomas (2021)
  • García-Díaz, Nuria; Casar, Berta; Alonso Alonso, Ruth; Quevedo, Laura; Rodríguez, Marta; Ruso-Julve, Fulgencio; Esteve-Codina, Anna; Gut, Marta; Gru, Alejandro A.; González Vela, María del Carmen; Gut, Ivo Glynne; Rodriguez-Peralto, José Luis; Varela, Ignacio; Ortiz-Romero, Pablo L.; Piris, Miguel A.; Vaqué, José Pedro (Elsevier, 2021)
    Developing mechanistic rationales can improve the clinical management of cutaneous T-cell lymphomas. There is considerable genetic and biological evidence of a malignant network of signaling mechanisms, highly influenced ...
  • Dios Martínez, Toni de, 1994-; Carrión, Pablo; Olalde Marquínez, Íñigo, 1987-; Llovera Nadal, Laia; Lizano González, Esther, 1974-; Pàmies, Dídac; Marquès i Bonet, Tomàs, 1975-; Balloux, François; van Dorp, Lucy; Lalueza Fox, Carles, 1965- (Elsevier, 2021)
    Ancient pathogen genomics is an emerging field allowing reconstruction of past epidemics. The demise of post-contact American populations may, at least in part, have been caused by paratyphoid fever brought by Europeans. ...
  • Burgos, Raul; Weber, Marc; Gallo López, Carolina, 1984-; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Elsevier, 2021)
    Trans-translation is a ubiquitous bacterial mechanism of ribosome rescue mediated by a transfer-messenger RNA (tmRNA) that adds a degradation tag to the truncated nascent polypeptide. Here, we characterize this quality ...
  • Nieto, Paula; Elosua-Bayés, Marc; Trincado Alonso, Juan Luis, 1987-; Marchese, Domenica, 1986-; Massoni-Badosa, Ramon; Nieto, Juan C.; Aguilar-Fernández, Sergio; Mereu, Elisabetta; Moutinho, Catia; Ruiz, Sara; Lorden, Patricia; Gut, Ivo Glynne; Heyn, Holger (Cold Spring Harbor Laboratory Press (CSHL Press), 2021)
    The tumor immune microenvironment is a main contributor to cancer progression and a promising therapeutic target for oncology. However, immune microenvironments vary profoundly between patients, and biomarkers for prognosis ...
  • Rovira Clusellas, Meritxell; Atla, Goutham; Maestro, Miguel Ángel; Grau, Vanessa; García-Hurtado, Javier; Maqueda, Maria; Mosquera, Jose Luis; Yamada, Yasuhiro; Kerr-Conte, Julie; Pattou, Francois; Ferrer, Jorge (Cold Spring Harbor Laboratory Press (CSHL Press), 2021)
    Multiple transcription factors have been shown to promote pancreatic β-cell differentiation, yet much less is known about negative regulators. Earlier epigenomic studies suggested that the transcriptional repressor REST ...
  • Martínez-Torró, Carlos; Torres-Puig, Sergi; Marcos-Silva, Marina; Huguet-Ramón, Marta; Muñoz-Navarro, Carmen; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982-; Querol, Enrique; Piñol, Jaume; Pich, Oscar Q. (Frontiers Media, 2021)
    It is well-established that FtsZ drives peptidoglycan synthesis at the division site in walled bacteria. However, the function and conservation of FtsZ in wall-less prokaryotes such as mycoplasmas are less clear. In the ...
  • Tejedor Vaquero, Sonia, 1988-; Campos Mata, Leire de, 1991-; Ramada Rodilla, José María, 1961-; Díaz, Pilar; Navarro-Barriuso, Juan; Ribas-Llauradó, Clara; Rodrigo Melero, Natalia; Carolis, Carlo; Cerutti, Andrea, 1965-; Gimeno Martínez, Ramón; Magri, Giuliana, 1978- (Frontiers Media, 2021)
    mRNA-based vaccines effectively induce protective neutralizing antibodies against SARS-CoV-2, the etiological agent of COVID-19. Yet, the kinetics and compositional patterns of vaccine-induced antibody responses to the ...
  • Papadopoulou, Eleni, 1985-; Basagaña Flores, Xavier; Casas Sanahuja, Maribel; Fossati, Serena; Maitre, Léa; Sabidó Aguadé, Eduard, 1981-; Borràs, Eva; Urquiza, José M.; Vrijheid, Martine; Chatzi, Leda (Elsevier, 2021)
    Developing children are particularly vulnerable to the effects of exposure to per- and polyfluoroalkyl substances (PFAS), a group of endocrine disrupting chemicals. We hypothesized that early life exposure to PFASs is ...
  • Marruecos, Laura; Bertran, Joan; Álvarez-Villanueva, Daniel; Mulero, María Carmen; Guillén, Yolanda; Palma, Luis G.; Floor, Martin; Vert, Anna; Arce-Gallego, Sara; Pecharroman, Irene; Batlle Masó, Laura, 1993-; Villà i Freixa, Jordi; Ghosh, Gourisankar; Bigas Salvans, Anna; Espinosa Blay, Lluís (Wiley, 2021)
    IκBs exert principal functions as cytoplasmic inhibitors of NF-kB transcription factors. Additional roles for IκB homologues have been described, including chromatin association and transcriptional regulation. Phosphorylated ...
  • White, Anna E.; Dios Martínez, Toni de, 1994-; Carrión, Pablo; Bonora, Gian Luca; Llovera Nadal, Laia; Cilli, Elisabetta; Lizano González, Esther, 1974-; Khabdulina, Maral K.; Tleugabulov, Daniyar T.; Olalde Marquínez, Íñigo, 1987-; Marquès i Bonet, Tomàs, 1975-; Balloux, François; Pettener, Davide; van Dorp, Lucy; Luiselli, Donata; Lalueza Fox, Carles, 1965- (MDPI, 2021)
    The Asian Central Steppe, consisting of current-day Kazakhstan and Russia, has acted as a highway for major migrations throughout history. Therefore, describing the genetic composition of past populations in Central Asia ...
  • Dhandapani, Laasya; Salzer, Marion C.; Duran, Juan M.; Zaffagnini, Gabriele; De Guirior, Cristian; Martínez-Zamora, Maria Angeles; Böke, Elvan (Company of Biologists, 2022)
    Oocytes spend the majority of their lifetime in a primordial state. The cellular and molecular biology of primordial oocytes is largely unexplored; yet, it is necessary to study them to understand the mechanisms through ...
  • Raote, Ishier; Saxena, Sonashree; Campelo, Felix; Malhotra, Vivek (Elsevier, 2021)
    TANGO1 protein facilitates the endoplasmic reticulum (ER) export of large cargoes that cannot be accommodated in 60 nm transport vesicles. It assembles into a ring in the plane of the ER membrane to create a distinct domain. ...
  • Alemany, Silvia; Vilor Tejedor, Natàlia, 1988-; Milà Alomà, Marta; Suárez-Calvet, Marc; Salvadó, Gemma; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Grau-Rivera, Oriol; Minguillón, Carolina; Fauria, Karine; Domingo Gispert, Juan; Gascon Merlos, Mireia, 1984-; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi; ALFA Study (Elsevier, 2021)
    Background: Air quality contributes to incidence of Alzheimer's disease (AD) although the underlying neurobiological mechanisms are unclear. This study was aimed to examine the association between air pollution and ...
  • Garrison, Helen; Agostinho, Marta; Alvarez, Laura; Bekaert, Sofia; Bengtsson, Luiza; Broglio, Elisabetta; Couso, Digna; Araújo Gomes, Raquel; Ingram, Zoe; Martínez, Emma; Mena, Ana Lúcia; Nickel, Dörthe; Norman, Michael; Pinheiro, Inês; Solís-Mateos, Marta; Bertero, Michela G. (EMBO Press, 2021)
    Open Science calls for transparent science and involvement of various stakeholders. Here are examples of and advice for meaningful stakeholder engagement.

View more