Articles (Center for Genomic Regulation (CRG))

 

Recent Submissions

  • Lleó, Alberto; Chiva, Cristina; Sabidó Aguadé, Eduard, 1981-; Belbin, Olivia (Elsevier, 2019)
    A biomarker of synapse loss, an early event in Alzheimer's disease (AD) pathophysiology that precedes neuronal death and symptom onset, would be a much-needed prognostic biomarker. With direct access to the brain interstitial ...
  • Strozzi, Francesco; Jansenn, Roel; Wurmus, Ricardo; Crusoe, Michael R.; Githinji, George; Di Tommaso, Paolo; Belhachemi, Dominique; Möller, Steffen; Smant, Geert; de Ligt, Joep; Prins, Pjotr (Springer, 2019)
    Biological, clinical, and pharmacological research now often involves analyses of genomes, transcriptomes, proteomes, and interactomes, within and between individuals and across species. Due to large volumes, the analysis ...
  • Garcia Valero, Juan; Matas-Céspedes, Alba; Arenas, Fabián; Rodriguez, Vanina; Carreras, Joaquim; Serrat, Neus; Guerrero-Hernández, Martina; Yahiaoui, Anella; Balagué, Olga; Martin, Silvia; Capdevila, Cristina; Hernández, Lluis; Magnano, Laura; Rivas-Delgado, Alfredo; Tannheimer, Stacey; Cid, Maria C.; Campo, Elias; López Guillermo, Armando; Colomer, Dolors; Pérez-Galán, Patricia (Springer Nature, 2021)
    Microenvironment contributes to follicular lymphoma (FL) pathogenesis and impacts survival with macrophages playing a controversial role. In the present study, using FL primary samples and HK follicular dendritic cells ...
  • Pry, Jake; Chipungu, Jenala; Smith, Helene J.; Bolton Moore, Carolyn; Mutale, Jacob; Duran-Frigola, Miquel, 1985-; Savory, Theodora; Herce, Michael E. (Wiley Open Access, 2020)
    Introduction: In the current "test and treat" era, HIV programmes are increasingly focusing resources on linkage to care and same-day antiretroviral therapy (ART) initiation to meet UNAIDS 95-95-95 targets. After observing ...
  • Sancho-Shimizu, Vanessa; Brodin, Petter; Cobat, Aurélie; Biggs, Catherine M.; Toubiana, Julie; Lucas, Carrie L.; Henrickson, Sarah E.; Belot, Alexandre; MIS-C@CHGE; Tangye, Stuart G.; Milner, Joshua D.; Levin, Michael; Abel, Laurent; Bogunovic, Dusan; Casanova, Jean-Laurent; Zhang, Shen-Ying; Gut, Marta (Rockefeller University Press, 2021)
    Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood ...
  • Martínez-Riaño, Ana; Bovolenta, Elena R.; Boccasavia, Viola L.; Ponomarenko, Julia; Abia, David; Oeste, Clara L.; Fresno, Manuel; van Santen, Hisse M.; Alarcon, Balbino (Rockefeller University Press, 2019)
    Signal strength controls the outcome of αβ T cell selection in the thymus, resulting in death if the affinity of the rearranged TCR is below the threshold for positive selection, or if the affinity of the TCR is above the ...
  • Pérez-Pérez, Martin; Pérez-Rodríguez, Gael; Blanco-Míguez, Aitor; Fdez-Riverola, Florentino; Valencia, Alfonso; Krallinger, Martin; Lourenço, Anália (Springer, 2019)
    Background: Shared tasks and community challenges represent key instruments to promote research, collaboration and determine the state of the art of biomedical and chemical text mining technologies. Traditionally, such ...
  • Castilla-Vallmanya, Laura; Gürsoy, Semra; Bozkaya, Özlem Giray; Prats-Planas, Aina; Bullich, Gemma; Matalonga, Leslie; Centeno-Pla, Mónica; Rabionet Janssen, Raquel; Grinberg, Daniel; Balcells, Susana; Urreizti, Roser (MDPI, 2021)
    We present a Turkish family with two cousins (OC15 and OC15b) affected with syndromic developmental delay, microcephaly, and trigonocephaly but with some phenotypic traits distinct between them. OC15 showed asymmetrical ...
  • Mateo, Lidia; Duran-Frigola, Miquel, 1985-; Gris-Oliver, Albert; Palafox, Marta; Scaltriti, Maurizio; Razavi, Pedram; Chandarlapaty, Sarat; Arribas, Joaquín; Bellet, Meritxell; Serra, Violeta; Aloy, Patrick, 1972- (BioMed Central, 2020)
    Identification of actionable genomic vulnerabilities is key to precision oncology. Utilizing a large-scale drug screening in patient-derived xenografts, we uncover driver gene alteration connections, derive driver co-occurrence ...
  • Baud, Amelie; Casale, Francesco Paolo; Barkley-Levenson, Amanda M.; Farhadi, Nilgoun; Montillot, Charlotte; Yalcin, Binnaz; Nicod, Jerome; Palmer, Abraham A.; Stegle, Oliver (BioMed Central, 2021)
    Background: The phenotype of an individual can be affected not only by the individual's own genotypes, known as direct genetic effects (DGE), but also by genotypes of interacting partners, indirect genetic effects (IGE). ...
  • Dolgova, Olga; Lao Grueso, Oscar, 1976- (MDPI, 2018)
    Evolutionary medicine applies the principles of evolutionary biology to understand why we get sick rather than how, and it has undergone an exponential growth since the early 1990s [...].
  • Faure, Andre J.; Domingo, Júlia; Schmiedel, Jörn M.; Hidalgo-Carcedo, Cristina; Diss, Guillaume; Lehner, Ben, 1978- (2022)
    Allosteric communication between distant sites in proteins is central to biological regulation but still poorly characterized, limiting understanding, engineering and drug development1-6. An important reason for this is ...
  • Mas, Glòria; Santoro, Fabio; Blanco, Enrique; Gamarra Figueroa, Gianni Paolo; Le Dily, François; Frigè, Gianmaria; Vidal, Enrique; Mugianesi, Francesca; Ballaré, Cecilia Julia; Gutiérrez, Arantxa; Sparavier, Aleksandra; Marti-Renom, Marc A.; Minucci, Saverio; Di Croce, Luciano (Cold Spring Harbor Laboratory Press (CSHL Press), 2022)
    Genome organization plays a pivotal role in transcription, but how transcription factors (TFs) rewire the structure of the genome to initiate and maintain the programs that lead to oncogenic transformation remains poorly ...
  • Baldassarri, Margherita; Gut, Marta; GEN-COVID Multicenter Study (Elsevier, 2021)
    Background: While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. Methods: We compared poly-amino ...
  • Brown, Peter; Raote, Ishier; RELISH Consortium; Zhou, Yaoqi (Oxford University Press, 2019)
    Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that ...
  • Anguera, Montserrat; Payer, Bernhard, 1975-; Morey, Céline (Frontiers, 2020)
  • Palmada-Flores, Marc; Orkin, Joseph D.; Haase, Bettina; Mountcastle, Jacquelyn; Bertelsen, Mads F.; Fedrigo, Olivier; Kuderna, Lukas F.K.; Jarvis, Erich D.; Marquès i Bonet, Tomàs, 1975- (Oxford University Press, 2022)
    Background: The ring-tailed lemur (Lemur catta) is a charismatic strepsirrhine primate endemic to Madagascar. These lemurs are of particular interest, given their status as a flagship species and widespread publicity in ...
  • Vonesch, Sibylle C.; Li, Shengdi; Szu-Tu, Chelsea; Henning, Bianca P.; Dobrev, Nikolay; Steinmetz, Lars M. (Oxford University Press, 2021)
    Through the increase in the capacity of sequencing machines massively parallel sequencing of thousands of samples in a single run is now possible. With the improved throughput and resulting drop in the price of sequencing, ...
  • Ndondo, Alvin Pumelele; Eley, Brian; Wilmshurst , Jo Madeleine; Kakooza-Mwesige, Angelina; Giannoccaro, Maria Pia; Willison, Hugh J.; Rodríguez Cruz, Pedro M.; Heckmann, Jeannine M.; Bateman, Kathleen; Vincent, Angela (Frontiers Media, 2022)
    The direct impact and sequelae of infections in children and adults result in significant morbidity and mortality especially when they involve the central (CNS) or peripheral nervous system (PNS). The historical understanding ...
  • Della Marina, Adela; Wibbeler, Eva; Abicht, Angela; Kölbel, Heike; Lochmüller, Hanns; Roos, Andreas; Schara-Schmidt, Ulrike (Frontiers Media, 2020)
    Introduction: Congenital myasthenic syndromes (CMS) refer to a heterogenic group of neuromuscular transmission disorders. CMS-subtypes are diverse regarding exercise intolerance and muscular weakness, varying from mild ...

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