Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

Collections in this community

Recent Submissions

  • Ritschka, Birgit,1985-; Storer, Mekayla, 1981-; Mas Malavila, Alba; Heinzmann, Florian; Ortells Campos, Mª Carmen, 1984-; Morton, Jennifer P.; Sansom, Owen J.; Zender, Lars; Keyes, William M., 1973- (Cold Spring Harbor Laboratory Press (CSHL Press), 2017)
    Senescence is a form of cell cycle arrest induced by stress such as DNA damage and oncogenes. However, while arrested, senescent cells secrete a variety of proteins collectively known as the senescence-associated secretory ...
  • Gladyshev, Vadim N.; Guigó Serra, Roderic; Zhang, Yan (American Society for Biochemistry and Molecular Biology (ASBMB), 2016)
    The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known ...
  • Rapino, Francesca, 1982-; Robles, Eloy F.; Richter-Larrea, Jose A.; Kallin, Eric M.; Martinez-Climent, Jose A.; Graf, T. (Thomas) (Cell Press, 2013)
    Earlier work demonstrated that the transcription factor C/EBPα can convert immature and mature murine B lineage cells into functional macrophages. Testing >20 human lymphoma and leukemia B cell lines, we found that most ...
  • Reig-Valiente, Juan L.; Viruel, Juan; Sales, Ester; Marqués, Luis; Terol, Javier; Gut, Marta; Derdak, Sophia; Talón, Manuel; Domingo, Concha (Springer Open, 2016)
    Background. After its domestication, rice cultivation expanded from tropical regions towards northern latitudes with temperate climate in a progressive process to overcome limiting photoperiod and temperature conditions. ...
  • Al-Refaie, Nada; Padovani, Francesco; Hornung, Johanna; Pudelko, Lorenz; Binando, Francesca; Carmen Fabregat, Andrea del; Zhao, Qiuxia; Towbin, Benjamin D.; Sarinay Cenik, Elif; Stroustrup, Nicholas; Padeken, Jan; Schmoller, Kurt M.; Cabianca, Daphne S. (Nature Research, 2024)
    Chromatin architecture is a fundamental mediator of genome function. Fasting is a major environmental cue across the animal kingdom, yet how it impacts three-dimensional (3D) genome organization is unknown. Here we show ...
  • Faure, Andre J.; Martí Aranda, Aina; Hidalgo-Carcedo, Cristina; Beltran, Antoni; Schmiedel, Jörn M.; Lehner, Ben, 1978- (Nature Research, 2024)
    There are more ways to synthesize a 100-amino acid (aa) protein (20100) than there are atoms in the universe. Only a very small fraction of such a vast sequence space can ever be experimentally or computationally surveyed. ...
  • Rubio, Rocío; Macià, Dídac; Barrios, Diana; Vidal, Marta; Jiménez, Alfons; Molinos-Albert, Luis M.; Díaz, Natalia; Canyelles, Mar; Lara Escandell, Maria; Planchais, Cyril; Santamaria, Pere; Carolis, Carlo; Izquierdo, Luis; Aguilar, Ruth; Moncunill, Gemma; Dobaño, Carlota (Elsevier, 2024)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) studies usually rely on cross-sectional data of large cohorts but limited repeated samples, overlooking significant inter-individual antibody kinetic differences. ...
  • Braham, Asma; Lemelle, Laurence; Ducasse, Romain; Toukabri, Houyem; Mottin, Eleonore; Fabrèges, Benoit; Calvez, Vincent; Place, Christophe (Springer, 2024)
    Flagellar swimming hydrodynamics confers a recognized advantage for attachment on solid surfaces. Whether this motility further enables the following environmental cues was experimentally explored. Motile E. coli (OD ~ ...
  • Esteban-Collado, José; Fernández Mañas, Mar; Fernández-Moreno, Manuel; Maeso, Ignacio; Corominas Guiu, Montserrat; Serras Rigalt, Florenci (EMBO Press, 2024)
    Tumor necrosis factor receptors (TNFRs) control pleiotropic pro-inflammatory functions that range from apoptosis to cell survival. The ability to trigger a particular function will depend on the upstream cues, association ...
  • Marot-Lassauzaie, Valérie; Beneyto Calabuig, Sergi; Obermayer, Benedikt; Velten, Lars; Beule, Dieter; Haghverdi, Laleh (Oxford University Press, 2024)
    Motivation: Single-cell RNA sequencing (scRNA-seq) data are widely used to study cancer cell states and their heterogeneity. However, the tumour microenvironment is usually a mixture of healthy and cancerous cells and it ...
  • Barrero Asencio, Mercedes; Lazarenkov, Aleksey; Blanco, Enrique; Palma, Luis G.; López Rubio, Anna V.; Bauer, Moritz, 1987-; Bigas Salvans, Anna; Di Croce, Luciano; Sardina, Jose Luis; Payer, Bernhard (American Association for the Advancement of Science (AAAS), 2024)
    Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) requires activation of the pluripotency network and resetting of the epigenome by erasing the epigenetic memory of the somatic state. In female mouse ...
  • Garate,, Ximena; Gómez García, Pablo Aurelio; Fernández Merino, Manuel; Cadevall Anglès, Marta; Zhu, Chenggan; Castells García, Àlvaro, 1991-; Ed-Daoui, Ilyas; Martin, Laura; Ochiai, Hiroshi; Neguembor, Maria Victoria; Cosma, Maria Pia (Oxford University Press, 2024)
    During early development, gene expression is tightly regulated. However, how genome organization controls gene expression during the transition from naïve embryonic stem cells to epiblast stem cells is still poorly understood. ...
  • Carnevali, Davide; Zhong, Limei; González-Almela, Esther; Viana, Carlotta; Rotkevich, Mikhail; Wang, Aiping; Franco-Barranco, Daniel; González-Marfil, Aitor; Neguembor, Maria Victoria; Castells García, Àlvaro, 1991-; Arganda-Carreras, Ignacio; Cosma, Maria Pia (Springer, 2024)
    Cellular phenotypic heterogeneity is an important hallmark of many biological processes and understanding its origins remains a substantial challenge. This heterogeneity often reflects variations in the chromatin structure, ...
  • Toledano, Ignasi; Supek, Fran; Lehner, Ben (Nature Research, 2024)
    Premature termination codons (PTCs) cause ~10-20% of inherited diseases and are a major mechanism of tumor suppressor gene inactivation in cancer. A general strategy to alleviate the effects of PTCs would be to promote ...
  • Anglada-Girotto, Miquel; Ciampi, Ludovica; Bonnal, Sophie; Head, Sarah A.; Miravet Verde, Samuel, 1992-; Serrano Pubull, Luis, 1982- (Nature Research, 2024)
    Alternative splicing is crucial for cancer progression and can be targeted pharmacologically, yet identifying driver exons genome-wide remains challenging. We propose identifying such exons by associating statistically ...
  • Story, Benjamin A.; Velten, Lars; Mönke, Gregor; Annan, Ahrmad; Steinmetz, Lars M. (Oxford University Press, 2024)
    Clonal cell population dynamics play a critical role in both disease and development. Due to high mitochondrial mutation rates under both healthy and diseased conditions, mitochondrial genomic variability is a particularly ...
  • Lorenzini, Luigi; Vilor Tejedor, Natàlia, 1988-; Gispert López, Juan Domingo; Barkhof, Frederik (Wiley, 2024)
    Introduction: Unraveling how Alzheimer's disease (AD) genetic risk is related to neuropathological heterogeneity, and whether this occurs through specific biological pathways, is a key step toward precision medicine. ...
  • Samulenaite, Solveiga; García Blanco, Alejandra; Mayneris Perxachs, Jordi; Domingo Rodriguez, Laura, 1992-; Cabana-Domínguez, Judit; Fernàndez-Castillo, Noèlia; Gago-García, Edurne; Pineda-Cirera, Laura; Burokas, Aurelijus, 1982-; Espinosa-Carrasco, José; Arboleya, Silvia; Latorre, Jessica; Stanton, Catherine; Hosomi, Koji; Kunisawa, Jun; Cormand, Bru; Fernández Real, Jose M.; Maldonado, Rafael, 1961-; Martín García, Elena, 1975- (BMJ Publishing Group, 2024)
    Objective: Food addiction is a multifactorial disorder characterised by a loss of control over food intake that may promote obesity and alter gut microbiota composition. We have investigated the potential involvement of ...
  • Traveset Martínez, Laia; Cerdán Porqueras, Víctor; Huerga Encabo, Hector, 1989-; Avalle, Silvia; Esteve-Codina, Anna; Fornas Carreño, Oscar; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (American Society of Hematology, 2024)
    Hematopoietic stem cells (HSCs) readily recover from acute stress, but persistent stress can reduce their viability and long-term potential. Here, we show that the nuclear factor of activated T cells 5 (NFAT5), a transcription ...
  • Dios Martínez, Toni de; Fontseré Alemany, Clàudia, 1992-; Renom, Pere; Stiller, Josefin; Llovera Nadal, Laia; Uliano-Silva, Marcela; Sánchez-Gracia, Alejandro; Wright, Charlotte; Lizano González, Esther, 1974-; Caballero, Berta; Navarro i Cuartiellas, Arcadi, 1969-; Civit, Sergi; Robbins, Robert K.; Blaxter, Mark; Marquès i Bonet, Tomàs, 1975-; Vila, Roger; Lalueza Fox, Carles, 1965- (eLife, 2024)
    The Xerces Blue (Glaucopsyche xerces) is considered to be the first butterfly to become extinct in historical times. It was notable for its chalky lavender wings with conspicuous white spots on the ventral wings. The last ...

View more