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Comparative analysis of cancer genes in the human and chimpanzee genomes

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dc.contributor.author Puente, Xosé S.
dc.contributor.author Velasco, Gloria
dc.contributor.author Gutiérrez Fernández, Ana
dc.contributor.author Bertranpetit, Jaume, 1952-
dc.contributor.author King, Mary Claire
dc.contributor.author López Otín, Carlos
dc.date.accessioned 2012-05-08T08:13:47Z
dc.date.available 2012-05-08T08:13:47Z
dc.date.issued 2006
dc.identifier.citation Puente XS, Velasco G, Gutiérrez-Fernández A, Bertranpetit J, King MC, López-Otín C. Comparative analysis of cancer genes in the human and chimpanzee genomes. BMC Genomics. 2006;7:15. DOI: 10.1186/1471-2164-7-15
dc.identifier.issn 1471-2164
dc.identifier.uri http://hdl.handle.net/10230/16416
dc.description.abstract Background: Cancer is a major medical problem in modern societies. However, the incidence of this disease in non-human primates is very low. To study whether genetic differences between human and chimpanzee could contribute to their distinct cancer susceptibility, we have examined in the chimpanzee genome the orthologous genes of a set of 333 human cancer genes. Results: This analysis has revealed that all examined human cancer genes are present in chimpanzee, contain intact open reading frames and show a high degree of conservation between both species. However, detailed analysis of this set of genes has shown some differences in genes of special relevance for human cancer. Thus, the chimpanzee gene encoding p53 contains a Pro residue at codon 72, while this codon is polymorphic in humans and can code for Arg or Pro, generating isoforms with different ability to induce apoptosis or interact with p73. Moreover, sequencing of the BRCA1 gene has shown an 8 Kb deletion in the chimpanzee sequence that prematurely truncates the co-regulated NBR2 gene. Conclusion: These data suggest that small differences in cancer genes, as those found in tumor suppressor genes, might influence the differences in cancer susceptibility between human and chimpanzee. Nevertheless, further analysis will be required to determine the exact contribution of the genetic changes identified in this study to the different cancer incidence in non-human primates.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof BMC Genomics. 2006;7:15
dc.rights © 2006 Puente et al. Creative Commons Attribution License
dc.rights.uri http://creativecommons.org/licenses/by/2.0/
dc.subject.other Càncer -- Aspectes genètics
dc.subject.other Genètica molecular
dc.subject.other Primats -- Genètica
dc.title Comparative analysis of cancer genes in the human and chimpanzee genomes
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/1471-2164-7-15
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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