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SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements

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dc.contributor.author Castellano Hereza, Sergi
dc.contributor.author Gladyshev, Vadim N.
dc.contributor.author Guigó Serra, Roderic
dc.contributor.author Berry, Marla J.
dc.contributor.other Universitat Pompeu Fabra
dc.date.accessioned 2011-11-28T11:08:03Z
dc.date.available 2011-11-28T11:08:03Z
dc.date.issued 2008
dc.identifier.citation Castellano S, Gladyshev V N, Guigó R, Berry M J. SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements. Nucleic acids research. 2008; 36 supl 1: D332-D338. DOI 10.1093/nar/gkm731
dc.identifier.issn 0305-1048
dc.identifier.uri http://hdl.handle.net/10230/13147
dc.description.abstract Selenoproteins are a diverse group of proteins/nusually misidentified and misannotated in sequence/ndatabases. The presence of an in-frame UGA (stop)/ncodon in the coding sequence of selenoprotein/ngenes precludes their identification and correct/nannotation. The in-frame UGA codons are recoded/nto cotranslationally incorporate selenocysteine,/na rare selenium-containing amino acid. The development/nof ad hoc experimental and, more recently,/ncomputational approaches have allowed the efficient/nidentification and characterization of the/nselenoproteomes of a growing number of species./nToday, dozens of selenoprotein families have been/ndescribed and more are being discovered in recently/nsequenced species, but the correct genomic annotation/nis not available for the majority of these/ngenes. SelenoDB is a long-term project that aims to/nprovide, through the collaborative effort of experimental/nand computational researchers, automatic/nand manually curated annotations of selenoprotein/ngenes, proteins and SECIS elements. Version 1.0 of/nthe database includes an initial set of eukaryotic/ngenomic annotations, with special emphasis on the/nhuman selenoproteome, for immediate inspection/nby selenium researchers or incorporation into more/ngeneral databases. SelenoDB is freely available at/nhttp://www.selenodb.org.
dc.language.iso eng
dc.publisher Oxford University Press
dc.rights (c) 2007 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Published article is also available at http://nar.oxfordjournals.org/content/36/suppl_1/D332.
dc.rights.uri http://creativecommons.org/licenses/by-nc/2.0/uk/
dc.subject.other Biologia molecular
dc.subject.other Bioinformàtica
dc.subject.other Genòmica -- Bases de dades
dc.subject.other Genòmica -- Informàtica
dc.title SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/nar/gkm731
dc.subject.keyword 3'UTR
dc.subject.keyword Protein databases
dc.subject.keyword Genomics
dc.subject.keyword Humans
dc.subject.keyword Internet
dc.subject.keyword Selenoproteins
dc.subject.keyword Protein Sequence Analysis
dc.subject.keyword RNA Sequence Analysis
dc.subject.keyword User-Computer Interface
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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