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Prenatal exposure to traffic-related air pollution and ultrasound measures of fetal growth in the INMA Sabadell cohort

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dc.contributor.author Aguilera Jiménez, Inmaculada, 1977-
dc.contributor.author García Esteban, Raquel
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Iñiguez, Carmen
dc.contributor.author Nieuwenhuijsen, Mark J.
dc.contributor.author Rodríguez, Agueda
dc.contributor.author Paez, Montserrat
dc.contributor.author Ballester Díez, Ferran
dc.date.accessioned 2011-06-01T11:01:33Z
dc.date.available 2011-06-01T11:01:33Z
dc.date.issued 2010
dc.identifier.citation Aguilera I, Garcia-Esteban R, Iñiguez C, Nieuwenhuijsen MJ, Rodríguez, À, Paez M. Prenatal exposure to traffic-related air pollution and ultrasound measures of fetal growth in the INMA Sabadell cohort. Environ Health Perspect. 2010; 118(5): 705-11. DOI 10.1289/ehp.0901228
dc.identifier.issn 1552-9924
dc.identifier.uri http://hdl.handle.net/10230/11706
dc.description.abstract Background: Few studies have used longitudinal ultrasound measurements to assess the effect of traffic-related air pollution on fetal growth./nObjective: We examined the relationship between exposure to nitrogen dioxide (NO2) and aromatic hydrocarbons [benzene, toluene, ethylbenzene, m/p-xylene, and o-xylene (BTEX)] on fetal growth assessed by 1,692 ultrasound measurements among 562 pregnant women from the Sabadell cohort of the Spanish INMA (Environment and Childhood) study./nMethods: We used temporally adjusted land-use regression models to estimate exposures to NO2 and BTEX. We fitted mixed-effects models to estimate longitudinal growth curves for femur length (FL), head circumference (HC), abdominal circumference (AC), biparietal diameter (BPD), and estimated fetal weight (EFW). Unconditional and conditional SD scores were calculated at 12, 20, and 32 weeks of gestation. Sensitivity analyses were performed considering time–activity patterns during pregnancy./nResults: Exposure to BTEX from early pregnancy was negatively associated with growth in BPD during weeks 20–32. None of the other fetal growth parameters were associated with exposure to air pollution during pregnancy. When considering only women who spent 2 hr/day in nonresidential outdoor locations, effect estimates were stronger and statistically significant for the association between NO2 and growth in HC during weeks 12–20 and growth in AC, BPD, and EFW during weeks 20–32./nConclusions: Our results lend some support to an effect of exposure to traffic-related air pollutants from early pregnancy on fetal growth during mid-pregnancy.
dc.description.sponsorship This study was funded by grants from the European Union: NEWGENERIS FP6-2003- Food-3-A-016320, FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5-1; and by grants from Spain: Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0031, and FIS-FEDER PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI04/2018, PI04/1436, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI08/1151, PI09/02647, PI09/02311, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/02429, PI14/0891, PI14/1687, and Miguel Servet CP11/00178 and MS13/00054), Conselleria de Sanitat Generalitat Valenciana, Generalitat de Catalunya (CIRIT 1999SGR 00241), Diputación Foral de Guipúzcoa (DFG/004), Departamento de Sanidad y Consumo Gobierno Vasco (2005111093), Obra Social Cajastur, and Oviedo University.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher National Institute of Environmental Health Sciences
dc.relation.ispartof Environmental Health Perspectives. 2010; 118(5): 705-11
dc.rights (c) National Institute of Environmental Health Sciences
dc.subject.other Sabadell (Catalunya) -- Condicions ambientals
dc.subject.other Aire -- Contaminació -- Catalunya -- Sabadell
dc.subject.other Embaràs -- Catalunya -- Sabadell
dc.subject.other Pes al néixer -- Catalunya -- Sabadell
dc.title Prenatal exposure to traffic-related air pollution and ultrasound measures of fetal growth in the INMA Sabadell cohort
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1289/ehp.0901228
dc.subject.keyword Air pollution
dc.subject.keyword Aromatic hydrocarbons
dc.subject.keyword Cohort study
dc.subject.keyword Exposure assessment
dc.subject.keyword Fetal growth
dc.subject.keyword INMA study
dc.subject.keyword Land use regression
dc.subject.keyword Ultrasonography
dc.subject.keyword Nitrogen dioxide
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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