Study of the hydroelectrolitic mass transfer of calcium in haemodialysis patients and its correlation to intradialytic hypotension and parathormone unbalances

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• dc.contributor.author Martínez Mas, Mar
• dc.date.accessioned 2021-07-19T10:24:11Z
• dc.date.available 2021-07-19T10:24:11Z
• dc.date.issued 2021-07
• dc.description Tutors: Maria Laura Costantino, Giustina Casagrande, Antoni Ivorra
• dc.description.abstract During haemodialysis, the composition of the dialysis fluid is typically prescribed by a nephrologist. Nevertheless, calcium and PTH unbalances, and the symptomatic hypotension that the patients suffer while undergoing haemodialysis therapy imply the need for changes in the calcium concentration of the dialysate, to improve its tolerance to HD. In this thesis it is proposed a model that allows us to know the balance of calcium together with the dialysis session, given a certain value of the initial calcium concentration and the patient characteristics. To this end, a model able to simulate and predict the patient’s specific response to HD treatment, taking into account the clinical conditions of the individual patient, has been designed and optimized. Calcium exchange is specifically modelled on the dialyzer, the vascular, the extracellular, the intracellular and the bone level. An analytical multi-pool model can be used to represent the body compartments and the dialyzer. Specific models describing only the calcium exchange during dialysis were available in the literature. Calcium peculiarities have been studied integrated into a multi-solute model already available at LaBS, DCMC, PoliMI. The results show that a a more accurate description of calcium metabolism in the model improves its prediction through simulations. An average prediction error of 1.83% was obtained with a maximum error obtained of 11%. Based on the simulation results and the analysis of patient-specific parameters, the proposed approach enables the extraction of conclusions regarding the relationships that exist between hypo and hyper calcemia generated in dialysis therapies and PTH unbalance and intradialytic hypotension cases. This way, dialysis planning would be facilitated and therapy complications reduced.ca
• dc.format.mimetype application/pdf*
• dc.identifier.uri http://hdl.handle.net/10230/48227
• dc.language.iso engca
• dc.rights © Tots els drets reservatsca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.keyword Haemodialysis
• dc.subject.keyword Parathormone Disorders
• dc.subject.keyword Hypotension
• dc.subject.keyword Dialysis Solution Concentration
• dc.subject.keyword Calcium Exchange Modelling
• dc.title Study of the hydroelectrolitic mass transfer of calcium in haemodialysis patients and its correlation to intradialytic hypotension and parathormone unbalancesca
• dc.type info:eu-repo/semantics/bachelorThesisca