A novel biophysical whole-brain model explains power spectrum alterations of serotonergic psychedelics
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- dc.contributor.author Cases Gendra, Jan
- dc.date.accessioned 2025-02-13T11:53:45Z
- dc.date.available 2025-02-13T11:53:45Z
- dc.date.issued 2024
- dc.description Treball de Fi de Grau en Enginyeria Biomèdica. Curs 2023-2024
- dc.description Tutors: Ralph G. Andrzejak, Giulio Ruffini, Francesca Castaldo i Edmundo Lopez-Solaca
- dc.description.abstract Background – Psychedelics hold great potential to treat various mental disorders, yet their neurobiological mechanisms remain unclear. Recent mechanistic models have provided valuable insights into the impact of serotonergic psychedelics on brain dynamics. However, these models focus mainly on macroscale brain activity and provide limited information on the psychedelics’ mechanisms at the neural population level. Methods – We provide a novel mechanistic explanation of the well-studied power spectrum alterations in spontaneous cortical activity observed under serotonergic psychedelics. We combine a physiologically grounded whole-brain model optimised with multimodal neuroimaging of healthy human participants with neurotransmitter data from positron emission tomography (PET) of the serotonin 2A receptor (5-HT2AR) density map. Building upon the recent laminar neural mass modelling (LaNMM) framework (Sanchez-Todo et al., 2023), the whole-brain model simulates multiband activity and electrophysiological measurements of the cortical columns, where the 5-HT2AR density controls the average synaptic gain of excitatory connections to layer 5 pyramidal neural populations, known to be rich in 5-HT2ARs. Results – Our findings suggest that the decrease in spontaneous cortical oscillatory power in the alpha band and increase in the gamma band are mainly influenced by the 5-HT2AR-mediated excitation of deep-layer pyramidal cells. These findings explain the functional effects of 5-HT2AR activation with psychedelics and allow us to propose a novel whole-brain biologically-informed explanation for this phenomenon detailed at the mesoscale and based on NMMs. Perspectives – This model provides valuable insight into the mechanistic underpinnings of psychedelic action in the brain and could be employed to investigate the neuromodulatory potential of psychedelics in re-establishing healthy brain dynamics in mental disorders.
- dc.identifier.uri http://hdl.handle.net/10230/69601
- dc.language.iso eng
- dc.rights This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0
- dc.subject.keyword Neuropsychiatryen
- dc.subject.keyword Psychedelicsen
- dc.subject.keyword Serotoninen
- dc.subject.keyword PETen
- dc.subject.keyword Whole-brain modelen
- dc.subject.keyword NMMen
- dc.subject.keyword Neuromodulationen
- dc.subject.other Treball de fi de grau – Curs 2023-2024
- dc.title A novel biophysical whole-brain model explains power spectrum alterations of serotonergic psychedelics
- dc.type info:eu-repo/semantics/bachelorThesis