Left Atrium blood flow characterization using 4D Flow MRI and CFD
Left Atrium blood flow characterization using 4D Flow MRI and CFD
Enllaç permanent
Descripció
Resum
Left atrial hemodynamics has acquired certain interest due to its role in the pathophysiology of thrombus formation in patients with atrial fibrillation. Computational fluid dynamics (CFD) has proven to be a valuable tool for studying blood flow dynamics while 4D Flow MRI is gaining importance for its ability to capture three-dimensional flow in vivo. The objective of this study was to assess differences in left atrial blood flow derived from in vivo flow velocities provided by a 4D Flow MRI of a real patient and CFD simulations with boundary conditions derived from this data. In the first part of the study, a pipeline for registration and visualization of left atrial flow from 4D Flow MRI velocity data was created. In the second part, we performed CFD simulations using boundary conditions derived from the 4D Flow data. The comparison of both techniques revealed some aspects of left atrial flow that were not captured in the CFD simulations, having made conventional assumptions about flow conditions such as laminarity, but also manifested the capabilities of 4D Flow MRI as a tool for validation of CFD models in the LA. This results further support that the combination of these techniques offers advantages relevant both for research and clinical applications.Descripció
Treball fi de màster de: Master in Computational Biomedical Engineering
Tutors: Óscar Cámara Rey, Andrea Guala