Development of a method to assess glycated albumin
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- dc.contributor.author Grifols i Vilella, Carlotaca
- dc.date.accessioned 2015-07-27T12:26:29Z
- dc.date.available 2015-07-27T12:26:29Z
- dc.date.issued 2015-07-27
- dc.description Treball de fi de grau en Biologia Humanaca
- dc.description Directora/supervisora del treball: Montse Costa
- dc.description Tutor UPF: Fèlix Bosch
- dc.description.abstract Albumin is the most abundant plasmatic protein as it corresponds to 50% of all the proteins found in plasma. It’s synthesised in the liver and it has a half-life of 19-21 days. Its importance lies on the multiple functions to which it has been associated to: regulates oncotic pressure, transports molecules and has a great antioxidant capacity among others. Albumin can also suffer glycation, a non-enzymatic process in/nwhich sugars are added to a molecule. This process can change albumin’s three-dimensional structure affecting its antioxidant and binding capacity. In the past years, the interest in studying albumin has increased due to its possible implications in different pathologies. Healthy people have a portion of albumin which has been glycated, but this level can be overcome in diseases like diabetes. In addition, as albumin’s half-life is lower than haemoglobin’s, it allows us to determine the glycaemic fluctuations up to 3 weeks before the extraction. For this reason, it is being studied the possibility of using glycated albumin as a glycaemic marker instead of haemoglobin. In this project we will try to validate a method to determine concentrations of glycated albumin.ca
- dc.format.mimetype application/pdfca
- dc.identifier.uri http://hdl.handle.net/10230/24656
- dc.language.iso engca
- dc.rights Attribution-NonCommercial 3.0 Spainca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/es/ca
- dc.subject.other Albúmina
- dc.subject.other Glicosilació
- dc.title Development of a method to assess glycated albuminca
- dc.type info:eu-repo/semantics/bachelorThesisca