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On the basis of impaired functional connectivity in psychosis: the role of structural substrate and neurometabolites contribution

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dc.contributor.author González Aranceta, Nerea
dc.date.accessioned 2023-09-22T17:20:33Z
dc.date.available 2023-09-22T17:20:33Z
dc.date.issued 2023-09-22
dc.identifier.uri http://hdl.handle.net/10230/57947
dc.description Tutores: Mireia Masias i Bruns, Dr. Gemma Piella Fenoy. Treball de fi de grau en Biomèdica
dc.description.abstract Psychotic disorders are characterized by the presence of symptoms related to a distortion of one’s perception of reality. In its early stages (First Episode of Psychosis, FEP), patients may show diffuse symptomatology that lays in a spectrum delimited by bipolarity and schizophrenia on both ends. Some studies point to a disconnection of the brain as a network as the most likely cause of the symptoms of the disease. Functional connectivity (FC) arises from the interaction of neurometabolites and a structural substrate, and inferring the contribution of each of these elements is not possible using traditional approaches. Accordingly, we aimed to explore the structural connectivity and use of simulations to infer the synaptic contribution of the emerging FC in FEP patients. First, structural connectivity from diffusion-weighted images was obtained and compared between Healthy Controls (HC), Affective Psychoses (AF), and Schizophrenia Spectrum Disorders. Second, synaptic-level properties, such as global connectivity, were inferred per subject based on Hopf-Bifurcation by selecting the parameters that produce the closest FC simulated to the experimental FC. Finally, a comparison of the extracted measures between the three groups was performed. The obtained results showed differences in the substrate of the three groups, with AF being the one with larger disparities from HC. As for the simulations, there were no differences for the global connectivities that generated the most accurate representation; however, for AF the similarity of the simulated static FC was lower to experimental static FC, which could suggest a higher neurometabolic contribution for this group.
dc.format.mimetype application/pdf
dc.language eng
dc.language.iso eng
dc.rights Llicència CC Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ca
dc.title On the basis of impaired functional connectivity in psychosis: the role of structural substrate and neurometabolites contribution
dc.type info:eu-repo/semantics/bachelorThesis
dc.subject.keyword First episode of psychosis
dc.subject.keyword Structural connectivity
dc.subject.keyword Synaptic-scale properties
dc.subject.keyword Restingstate Fmri
dc.subject.keyword Hopf bifurcation model
dc.rights.accessRights info:eu-repo/semantics/openAccess

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