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Nanoheaters and amoeboid-like motile cells: designing a new delivery system

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dc.contributor.author Bellot Herrero, Carlota
dc.date.accessioned 2018-09-13T11:26:23Z
dc.date.available 2018-09-13T11:26:23Z
dc.date.issued 2018-09-13
dc.identifier.uri http://hdl.handle.net/10230/35444
dc.description Treball de fi de grau en Biologia Humana
dc.description Tutora: Pilar Rivera Gil
dc.description.abstract Pharmacological success is strongly determined by how a drug is delivered to its target structure. This is the reason why the development of improved and new drug delivery strategies is one of the greatest pharmacological research focuses. The present work proposes a novel cell-based drug delivery system based on the use of fast migrating amoeboid-like fragments without nucleus and the photo-induced thermal properties of gold nanoheaters as release triggers. The objective is to determine the practical feasibility of this concept following different strategies, starting with the use of zebrafish embryo cells. This type of cells was later rejected for this aim due to the impossibility to load them with nanoheaters using the tested procedures. HeLa cells were then deemed as good candidates to orientate future proof-of-concept tests in this direction.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.rights © Tots els drets reservats
dc.subject.other Genètica
dc.subject.other Medicaments
dc.subject.other Medicaments -- Disseny
dc.title Nanoheaters and amoeboid-like motile cells: designing a new delivery system
dc.type info:eu-repo/semantics/bachelorThesis
dc.rights.accessRights info:eu-repo/semantics/openAccess


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