(Nature Research, 2025) Connelly, Katelyn E.; Hullin, Katherine; Abdolalizadeh, Ehssan; Zhong, Jun; Eiser, Daina; O'Brien, Aidan; Collins, Irene; Das, Sudipto; Duncan, Gerard; Pancreatic Cancer Cohort Consortium; Pancreatic Cancer Case-Control Consortium; Chanock, Stephen J.; Stolzenberg-Solomon, Rachael Z.; Klein, Alison P.; Wolpin, Brian M.; Hoskins, Jason W.; Andresson, Thorkell; Smith, Jill P.; Amundadottir, Laufey T.