Storer, Mekayla, 1981-Keyes, William M., 1973-2024-10-212024-10-212014Storer M, Keyes WM. Developing senescence to remodel the embryo. Communicative & Integrative Biology. 2014 Oct 20;7(5):e970969. DOI: 10.4161/cib.290981942-0889http://hdl.handle.net/10230/68244Cellular senescence is an irreversible form of cell cycle arrest that has been linked to several pathological conditions. In particular, senescence can function as a tumor suppressor mechanism, but is also thought to contribute to organismal aging. Paradoxically however, through the secretion of various factors, collectively termed the senescence-associated secretory phenotype (SASP), senescent cells can also have tumor-promoting and tissue-remodeling functions. In addition, senescent cells can play beneficial roles in tissue repair and wound healing, and reconciling these contradictory features from an evolutionary standpoint has been challenging. Moreover, senescent cells had not previously been documented in non-pathological conditions. Recently however, 2 studies have identified cellular senescence as a programmed mechanism that contributes to tissue patterning and remodeling during normal embryonic development. These findings have significant implications for our understanding of cellular senescence and help to clarify the paradoxes and the evolutionary origin of this process.application/pdfeng© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC. © Mekayla Storer and William M Keyes. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.info:eu-repo/semantics/articlehttp://dx.doi.org/10.4161/cib.29098EvolutionTumour suppressionAgingEmbryoSenescenceinfo:eu-repo/semantics/openAccess