Boutou, Afroditi K.Raste, YoginiDemeyer, HeleenTroosters, ThierryPolkey, Michael I.Vogiatzis, IoannisLouvaris, ZafeirisRabinovich, Roberto A.van der Molen, ThysGarcía Aymerich, Judith2020-02-062020-02-062019Boutou AK, Raste Y, Demeyer H, Troosters T, Polkey MI, Vogiatzis et al. Progression of physical inactivity in COPD patients: the effect of time and climate conditions - a multicenter prospective cohort study. Int J Chron Obstruct Pulmon Dis. 2019;14:1979-92. DOI: 10.2147/COPD.S2088261176-9106http://hdl.handle.net/10230/43501Purpose: Longitudinal data on the effect of time and environmental conditions on physical activity (PA) among COPD patients are currently scarce, but this is an important factor in the design of trials to test interventions that might impact on it. Thus, we aimed to assess the effect of time and climate conditions (temperature, day length and rainfall) on progression of PA in a cohort of COPD patients. Patients and methods: This is a prospective, multicenter, cohort study undertaken as part of the EU/IMI PROactive project, in which we assessed 236 COPD patients simultaneously wearing two activity monitors (Dynaport MiniMod and Actigraph GT3X). A multivariable generalized linear model analysis was conducted to describe the effect of the explanatory variables on PA measures, over three time points (baseline, 6 and 12 months). Results: At 12 months (n=157; FEV1% predicted=57.7±21.9) there was a significant reduction in all PA measures (Actigraph step count (4284±3533 vs 3533±293)), Actigraph moderate- to vigorous-intensity PA ratio (8.8 (18.8) vs 6.1 (15.7)), Actigraph vector magnitude units (374,902.4 (265,269) vs 336,240 (214,432)), MiniMod walking time (59.1 (34.9) vs 56.9 (38.7) mins) and MiniMod PA intensity (0.183 (0) vs 0.181 (0)). Time had a significant, negative effect on most PA measures in multivariable analysis, after correcting for climate factors, study center, age, FEV1% predicted, 6MWD and other disease severity measures. Rainfall was the only climate factor with a negative effect on most PA parameters. Conclusion: COPD patients demonstrate a significant decrease in PA over 1 year follow-up, which is further affected by hours of rainfall, but not by other climate considerations.application/pdfeng© 2019 Boutou et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License (https://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.info:eu-repo/semantics/articlehttp://dx.doi.org/10.2147/COPD.S208826Chronic obstructive pulmonary diseaseClimateElapsed timePhysical activityinfo:eu-repo/semantics/openAccess