José Segarra-Martínez, AnabelSobrevals, LucianoIvorra Cano, Antoni, 1974-Fillat i Fonts, Cristina2016-05-052016-05-052012José A, Sobrevals L, Ivorra A, Fillat C. Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models. Cancer Lett. 2012;317(1):16-23. DOI:10.1016/j.canlet.2011.11.0040304-3835http://hdl.handle.net/10230/26250Pancreatic Ductal Adenocarcinoma (PDAC) therapies show limited success./nIrreversible electroporation (IRE) is an innovative loco-regional therapy in which highvoltage pulses are applied to induce plasma membrane defects leading to cellular death. In the present study we evaluated the feasibility of IRE against PDAC. IRE/ntreatment exhibited significant antitumor effects and prolonged survival in mice with orthotopic xenografts. Extensive tumor necrosis, reduced tumor cell proliferation and disruption of microvessels were observed at different days post-IRE. Animals had transient increases in transaminases, amylase and lipase enzymes that normalized at/n24h post-IRE. These results suggest that IRE could be an effective treatment for locally advanced pancreatic tumors.application/pdfeng© Elsevier http://dx.doi.org/10.1016/j.canlet.2011.11.004info:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.canlet.2011.11.004Pancreatic ductal adenocarcinomaIrreversible electroporationOrthotopic pancreatic cancer xenograftsBioluminescent imaginginfo:eu-repo/semantics/openAccess