Pesqué, DavidCiudad, AndreaAndrades, EvelynSoto, DulceGimeno, RamónPujol Vallverdú, Ramon MariaGiménez Arnau, Anna Maria2024-09-252024-09-252024Pesqué D, Ciudad A, Andrades E, Soto D, Gimeno R, Pujol RM, et al. Solar urticaria: An ambispective study in a long-term follow-up cohort with emphasis on therapeutic predictors and outcomes. Acta Derm Venereol. 2024 Jan 8;104:adv25576. DOI: 10.2340/actadv.v104.255760001-5555http://hdl.handle.net/10230/61208Solar urticaria is a rare photodermatosis with several unknown pathogenic, clinical and therapeutic aspects. This study analysed the clinical and therapeutic features of a long-term follow-up solar urticaria cohort, with a focus on omalizumab management and outcomes, and characterized omalizumab response with the use of the high-affinity immunoglobulin E (IgE) receptor (FcεRI) and the Urticaria Control Test. An observational, unicentric, ambispective study was conducted from 2007 to 2023. Solar urticaria was diagnosed in 41 patients with a median follow-up of 60 months. Thirteen patients were prescribed omalizumab, with a median treatment time of 48 months. A significant decrease in FcεRI baseline levels and subsequent median increase in Urticaria Control Test was evidenced after omalizumab prescription in all patients. Drug survival at 48 months was at 88.9%. Omalizumab stepping-down protocol led to sustained omalizumab discontinuation in only 1 patient. Median basal Urticaria Control Test was lower (p < 0.01) in patients who were prescribed omalizumab and in patients without remission. This study contributes to our knowledge of omalizumab outcomes in real-life clinical practice and highlights the pathogenic importance of IgE-mediated pathways in solar urticaria, where FcεRI emerges as a possible biomarker of omalizumab response.application/pdfengPublished by Medical Journals Sweden, on behalf of the Society for Publication of Acta Dermato-Venereologica. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/).Solar urticaria: An ambispective study in a long-term follow-up cohort with emphasis on therapeutic predictors and outcomesinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.2340/actadv.v104.25576Chronic urticariaInducible urticariaOmalizumabPredictorSolar urticariaTreatmentinfo:eu-repo/semantics/openAccess