Climent Biescas, ElisendaGonzález-Guerrero, AntónMarco-Benedí, VictoriaGarcía Andreu, María del MarMediavilla, Juan DiegoSuárez-Tembra, ManuelBenaiges Foix, DavidPintó Sala, XavierPedro-Botet, Juan Carlos2025-04-042025-04-042024Climent E, González-Guerrero A, Marco-Benedí V, García-Andreu MD, Mediavilla-García JD, Suárez-Tembra M, et al. Resilient older subjects with heterozygous familial hypercholesterolemia, baseline differences and associated factors. Int J Mol Sci. 2024 Apr 29;25(9):4831. DOI: 10.3390/ijms250948311422-0067http://hdl.handle.net/10230/70089Despite elevated low-density lipoprotein (LDL) cholesterol levels, some older subjects with heterozygous familial hypercholesterolemia (HeFH) do not develop atherosclerotic cardiovascular disease (ACVD) during their lifetime. The factors related to this resilient state have not been fully established. The aim of this study was to evaluate differential characteristics between older HeFH subjects with and without ACVD and factors associated with the presence of ACVD. Subjects were part of the Spanish Atherosclerosis Society Dyslipidemia Registry, and those ≥ 70 years old and with HeFH were included. Baseline characteristics of these subjects with and without ACVD were compared. A multivariate analysis was performed to assess factors associated with the presence of ACVD. A total of 2148 subjects with HeFH were included. Resilient subjects were mostly female, younger and presented fewer comorbidities with respect to the ACVD group. Subjects without ACVD had higher baseline high-density lipoprotein (HDL) cholesterol (55.8 ± 17.1 vs. 47.9 ± 15.4 mg/dL; p < 0.001) and lower lipoprotein(a) [Lp(a)] (53.4 ± 67.9 vs. 66.6 ± 85.6 mg/dL; p < 0.001) levels with respect to those in the ACVD group. Lp(a) and the presence of ≥3 risk factors were associated with the presence of ACVD.application/pdfeng© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/ijms25094831Cardiovascular diseaseHeterozygous familial hypercholesterolemiaHigh-density lipoprotein cholesterolLipoprotein(a)OlderResilientinfo:eu-repo/semantics/openAccess