Espinosa Blay, Lluís2017-01-092017-01-092016Espinosa L. Endosomal acidification inhibitors for the treatment of BRAF mutant tumors. Mol Cell Oncol. 2015 Nov 18;3(2):e1062073. doi: 10.1080/23723556.2015.10620732372-3556http://hdl.handle.net/10230/27854Mutations in KRAS and BRAF genes are commonly found in several types of cancer associated with poor prognosis and therapy resistance. We have identified phosphorylated p45-IKKα as an essential mediator of BRAF-induced tumorigenesis. Importantly, endosomal acidification inhibitors preclude phosphorylation of p45-IKKα and abolish the metastatic capacity of BRAF mutant cancer cells.application/pdfengThis is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.Còlon -- CàncerCòlon -- Tumorsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/23723556.2015.1062073info:eu-repo/semantics/openAccess