Sanz, JavierEraso, ArantxaIbáñez, ReyesWilliams, RachelAlgara López, Manuel-Ignacio2024-03-142024-03-142023Sanz J, Eraso A, Ibáñez R, Williams R, Algara M. Tumor bed boost radiotherapy in the conservative treatment of breast cancer: a review of intra-operative techniques and outcomes. Cancers (Basel). 2023 Aug 8;15(16):4025. DOI: 10.3390/cancers151640252072-6694http://hdl.handle.net/10230/59410Conservative surgery is the preferred treatment in the management of breast cancer followed by adjuvant whole-breast irradiation. Since the tumor bed is the main site of relapse, boost doses are conveniently administered according to risk factors for local relapse to increase the efficacy of the treatment. The benefit of a radiation boost is well established and it can be performed by several techniques like brachytherapy, external radiation or intraoperative radiotherapy. Greater precision in localizing the tumor cavity, immediacy and increased biological response are the main advantages of intraoperative boost irradiation. This modality of treatment can be performed by means of mobile electron accelerators or low-photon X-ray devices. There is a lot of research and some published series analyzing the results of the use of an intraoperative boost as an adjuvant treatment, after neoadjuvant systemic therapy and in combination with some reconstructive surgeries. This review discusses advantages of intraoperative radiotherapy and presents the main results of a boost in terms of local control, survival, tolerance and cosmesis.application/pdfeng© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/cancers15164025Breast cancerConservative treatmentIntraoperative radiotherapyOutcomesTumor bed boostWhole breast irradiation (WBI)info:eu-repo/semantics/openAccess