Gutiérrez Sacristán, AlbaGuedj, RomainKorodi, GaborStedman, JasonFurlong, Laura I., 1971-Patel, Chirag J.Kohane, Isaac S.Avillach, Paul2018-10-112018-10-112018Gutiérrez-Sacristán A, Guedj R, Korodi G, Stedman J, Furlong LI, Patel CJ. Rcupcake: an R package for querying and analyzing biomedical data through the BD2K PIC-SURE RESTful API. Bioinformatics. 2018 Apr 15;34(8):1431-1432. DOI: 10.1093/bioinformatics/btx7881367-4803http://hdl.handle.net/10230/35595MOTIVATION: In the era of big data and precision medicine, the number of databases containing clinical, environmental, self-reported and biochemical variables is increasing exponentially. Enabling the experts to focus on their research questions rather than on computational data management, access and analysis is one of the most significant challenges nowadays. RESULTS: We present Rcupcake, an R package that contains a variety of functions for leveraging different databases through the BD2K PIC-SURE RESTful API and facilitating its query, analysis and interpretation. The package offers a variety of analysis and visualization tools, including the study of the phenotype co-occurrence and prevalence, according to multiple layers of data, such as phenome, exposome or genome.application/pdfengCopyright © The Author 2017. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comMacrodadesElectrònica mèdicainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1093/bioinformatics/btx788info:eu-repo/semantics/openAccess