Puighermanal Puigvert, Emma, 1983-Busquets Garcia, Arnau, 1985-Maldonado, Rafael, 1961-Ozaita Mintegui, Andrés, 1969-2015-03-272015-03-272012Puighermanal E, Busquets-Garcia A, Maldonado R, Ozaita A. Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3254-63. DOI: 10.1098/rstb.2011.03840962-8436http://hdl.handle.net/10230/23298Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds modulate a number of signalling pathways critically implicated in the deleterious effect of cannabinoids on learning and memory. Thus, the involvement of the mammalian target of rapamycin pathway and extracellular signal-regulated kinases, together with their consequent regulation of cellular processes such as protein translation, play a critical role in the amnesic-like effects of cannabinoids. In this study, we summarize the cellular and molecular mechanisms reported in the modulation of cognitive function by the endocannabinoid system.application/pdfeng© The Royal Society. http://dx.doi.org/10.1098/rstb.2011.0384Trastorns de la cognicióCannabinoidesinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1098/rstb.2011.0384info:eu-repo/semantics/openAccess