Bousquet, JeanHaahtela, TariBlain, HubertCzarlewski, WienczyslawaZuberbier, TorstenBedbrook, AnnaCruz, Alvaro A.Fonseca, Joao A.Klimek, LudgerKuna, PiotrSamolinski, BoleslawValiulis, ArunasLemaire, AntoineAntó i Boqué, Josep Maria2022-05-022022-05-022022Bousquet J, Haahtela T, Blain H, Czarlewski W, Zuberbier T, Bedbrook A, Cruz AA, Fonseca JA, Klimek L, Kuna P, Samolinski B, Valiulis A, Lemaire A, Anto JM. Available and affordable complementary treatments for COVID-19: From hypothesis to pilot studies and the need for implementation. Clin Transl Allergy. 2022 Mar;12(3):e12127. DOI: 10.1002/clt2.121272045-7022http://hdl.handle.net/10230/52951Vaccination is a highly effective preventive measure against COVID-19. However, complementary treatments are needed to better control the disease. Fermented vegetables and spices, agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and TRPA1/V1 channels (Transient Receptor Potential Ankyrin 1 and Vanillin 1), may help in the control of COVID-19. Some preliminary clinical trials suggest that curcumin (spice) can prevent some of the COVID-19 symptoms. Before any conclusion can be drawn and these treatments recommended for COVID-19, the data warrant confirmation. In particular, the benefits of the foods need to be assessed in more patients, through research studies and large trials employing a double-blind, placebo-controlled design.application/pdfeng© 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/clt2.12127COVID-19Nrf2TRP channelBroccoliCurcumininfo:eu-repo/semantics/openAccess