Sala, Romain W.Georgescu, Ioana A.Baba Aissa, Hindd’Almeida, Marion N.Popa, DanielaLéna, Clément2025-05-052025-05-052023Frontera JL, Sala RW, Georgescu IA, Baba H, d’Almeida MN, Popa D, et al. The cerebellum regulates fear extinction through thalamo-prefrontal cortex interactions in male mice. Nat Commun. 2023 Mar 17;14:1508. DOI: 10.1038/s41467-023-36943-w2041-1723http://hdl.handle.net/10230/70263Includes supplementary materials for the online appendix.Fear extinction is a form of inhibitory learning that suppresses the expression of aversive memories and plays a key role in the recovery of anxiety and trauma-related disorders. Here, using male mice, we identify a cerebello-thalamo-cortical pathway regulating fear extinction. The cerebellar fastigial nucleus (FN) projects to the lateral subregion of the mediodorsal thalamic nucleus (MD), which is reciprocally connected with the dorsomedial prefrontal cortex (dmPFC). The inhibition of FN inputs to MD in male mice impairs fear extinction in animals with high fear responses and increases the bursting of MD neurons, a firing pattern known to prevent extinction learning. Indeed, this MD bursting is followed by high levels of the dmPFC 4 Hz oscillations causally associated with fear responses during fear extinction, and the inhibition of FN-MD neurons increases the coherence of MD bursts and oscillations with dmPFC 4 Hz oscillations. Overall, these findings reveal a regulation of fear-related thalamo-cortical dynamics by the cerebellum and its contribution to fear extinction.application/pdfengThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Sistema límbicCircuit neuronalCerebel -- Malaltiesinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41467-023-36943-winfo:eu-repo/semantics/openAccess