Curado, JoaoIannone, Camilla, 1984-Tilgner, Hagen, 1980-Valcárcel, J. (Juan)Guigó Serra, Roderic2015-11-202015-11-202015Curado J, Iannone C, Tilgner H, Valcárcel J, Guigó R. Promoter-like epigenetic signatures in exons displaying cell type-specific splicing. Genome Biology. 2015;16:236. DOI: 10.1186/s13059-015-0797-81465-6906http://hdl.handle.net/10230/25168Un erratum d'aquest article s'ha publicat a Erratum to: Promoter-like epigenetic signatures in exons displaying cell type-specific splicing-Genome biology, 2016, 17(1), 52. DOI: 10.1186/s13059-016-0890-7 i també està disponible a http://hdl.handle.net/10230/26093Background. Pre-mRNA splicing occurs mainly co-transcriptionally, and both nucleosome density and histone modifications have been proposed to play a role in splice site recognition and regulation. However, the extent and mechanisms behind this interplay remain poorly understood./nResults. We use transcriptomic and epigenomic data generated by the ENCODE project to investigate the association between chromatin structure and alternative splicing. We find a strong and significant positive association between H3K9ac, H3K27ac, H3K4me3, epigenetic marks characteristic of active promoters, and exon inclusion in a small but well-defined class of exons, representing approximately 4 % of all regulated exons. These exons are systematically maintained at comparatively low levels of inclusion across cell types, but their inclusion is significantly enhanced in particular cell types when in physical proximity to active promoters./nConclusion. Histone modifications and other chromatin features that activate transcription can be co-opted to participate in the regulation of the splicing of exons that are in physical proximity to promoter regions.application/pdfeng© 2015 Curado et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.CromatinaHistonesEpigènesiinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s13059-015-0797-8ChromatinSplicingHistoneModificationsPromotersProximityTranscriptionEpigeneticRNAENCODEinfo:eu-repo/semantics/openAccess