Navarro, JudithGozalbo-López, BeatrizMéndez, Andrea C.Dantzer, FrançoiseSchreiber, ValérieMartínez, CarlosArana, David M.Farrés, JordiRevilla-Nuin, BeatrizBueno, María F.Ampurdanés, CoralGalindo-Campos, Miguel A.Knobel, Philip A.Segura-Bayona, SandraMartín Caballero, JuanStracker, TravisAparicio, PedroDel Val, MargaritaYélamos López, José2018-03-062018-03-062017Navarro J, Gozalbo-López B, Méndez AC, Dantzer F, Schreiber V, Martínez C. et al. PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas. Sci Rep. 2017 Feb 9;7:41962. DOI: 10.1038/srep419622045-2322http://hdl.handle.net/10230/34049The maintenance of T-cell homeostasis must be tightly regulated. Here, we have identified a coordinated role of Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 in maintaining T-lymphocyte number and function. Mice bearing a T-cell specific deficiency of PARP-2 in a PARP-1-deficient background showed defective thymocyte maturation and diminished numbers of peripheral CD4+ and CD8+ T-cells. Meanwhile, peripheral T-cell number was not affected in single PARP-1 or PARP-2-deficient mice. T-cell lymphopenia was associated with dampened in vivo immune responses to synthetic T-dependent antigens and virus, increased DNA damage and T-cell death. Moreover, double-deficiency in PARP-1/PARP-2 in T-cells led to highly aggressive T-cell lymphomas with long latency. Our findings establish a coordinated role of PARP-1 and PARP-2 in T-cell homeostasis that might impact on the development of PARP-centred therapies.application/pdfengCopyright © 2017, The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/Limfomes -- Tractamentinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/srep41962info:eu-repo/semantics/openAccess