Garcia Canadilla, PatriciaDejea i Velardo, HèctorBonnin, AnneBalicevic, VedranaLoncaric, SvenZhang, ChongButakoff, ConstantineAguado-Sierra, JazminVázquez, MarianoJackson, Laurence H.Stuckey, Daniel J.Rau, CristophStampanoni, MarcoBijnens, BartCook, Andrew C.2019-03-272018Garcia-Canadilla P, Dejea H, Bonnin A, Balicevic V, Loncaric S, Zhang C, Butakoff C, Aguado-Sierra J, Vázquez M, Jackson LH, Stuckey DJ, Rau C, Stampanoni M, Bijnens B, Cook AC. Complex congenital heart disease associated with disordered myocardial architecture in a midtrimester human fetus. Circ Cardiovasc Imaging. 2018 Oct 15;11(10):e007753. DOI: 10.1161/CIRCIMAGING.118.0077531941-9651http://hdl.handle.net/10230/36985In the era of increasingly successful corrective interventions in patients with congenital heart disease (CHD), global and regional myocardial remodeling are emerging as important sources of long-term morbidity/mortality. Changes in organization of the myocardium in CHD, and in its mechanical properties, conduction, and blood supply, result in altered myocardial function both before and after surgery. To gain a better understanding and develop appropriate and individualized treatment strategies, the microscopic organization of cardiomyocytes, and their integration at a macroscopic level, needs to be completely understood. The aim of this study is to describe, for the first time, in 3 dimensions and nondestructively the detailed remodeling of cardiac microstructure present in a human fetal heart with complex CHD.application/pdfeng© American Hearth Association http://dx.doi.org/10.1161/CIRCIMAGING.118.007753info:eu-repo/semantics/articlehttp://dx.doi.org/10.1161/CIRCIMAGING.118.007753IsomerismSynchrotronsHumansMyocardiumFetal heartX-ray microtomographyinfo:eu-repo/semantics/openAccess