Coca, ArmandoBurballa Tàrrega, Carla, 1988-Centellas-Pérez, Francisco JavierPérez-Sáez, María JoséBustamante-Munguira, ElenaOrtega, AgustínDueñas Gutiérrez, CarlosArenas Jiménez, María DoloresPérez-Martínez, JuanRuiz, GuadalupeCrespo Barrio, MartaLlamas, FranciscoBustamante-Munguira, JuanPascual Santos, Julio2021-06-302021-06-302020Coca A, Burballa C, Centellas-Pérez FJ, Pérez-Sáez MJ, Bustamante-Munguira E, Ortega A, et al. Outcomes of COVID-19 among hospitalized patients with non-dialysis CKD. Front Med. 2020 Dec 3; 7: 615312. DOI: 10.3389/fmed.2020.6153122296-858Xhttp://hdl.handle.net/10230/48012Background: Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome-Corona Virus 2 has generated significant impact on global health worldwide. COVID-19 can cause pneumonia and organ injury. Chronic kidney disease (CKD) has been associated with increased mortality in previous epidemics, but there is a paucity of data regarding actual risks for non-dialysis CKD patients with COVID-19. Methods: Multicenter, observational cohort study including 136 non-dialysis CKD patients and 136 age- and sex-matched controls that required hospitalization due to COVID-19. Patients with end-stage renal disease, a kidney transplant or without registered baseline glomerular filtration rate prior to COVID-19 infection were excluded. CKD and acute kidney injury (AKI) were defined according to KDIGO criteria. Results: CKD patients had higher white blood cell count and D-dimer and lower lymphocyte percentage. No differences were found regarding symptoms on admission. CKD was associated with higher rate of AKI (61 vs. 24.3%) and mortality (40.4 vs. 24.3%). Patients with AKI had the highest hazard for death (AKI/non-CKD HR:7.04, 95% CI:2.87-17.29; AKI/CKD HR:5.25, 95% CI: 2.29-12.02), followed by CKD subjects without AKI (HR:3.39, 95% CI:1.36-8.46). CKD status did not condition ICU admission or length of in-hospital stay. Conclusions: CKD patients that require hospitalization due to COVID-19 are exposed to higher risk of death and AKI.application/pdfengCopyright © 2020 Coca, Burballa, Centellas-Pérez, Pérez-Sáez, Bustamante Munguira, Ortega, Dueñas, Arenas, Pérez-Martínez, Ruiz, Crespo, Llamas, Bustamante-Munguira and Pascual. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) http://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.info:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fmed.2020.615312COVID−19Acute kidney damageChornic kidney diseasePneumoniaRenal failureinfo:eu-repo/semantics/openAccess