Ferro, DemetrioCash-Padgett, TylerWang, Maya ZheHayden, Benjamin Y.Moreno-Bote, Ruben2025-06-172025-06-172024Ferro D, Cash-Padgett T, Wang MZ, Hayden BY, Moreno Bote R. Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex. Nat Commun. 2024;15:6163. DOI: 10.1038/s41467-024-50214-22041-1723http://hdl.handle.net/10230/70699During economic choice, options are often considered in alternation, until commitment. Nonetheless, neuroeconomics typically ignores the dynamic aspects of deliberation. We trained two male macaques to perform a value-based decision-making task in which two risky offers were presented in sequence at the opposite sides of the visual field, each followed by a delay epoch where offers were invisible. Surprisingly, during the two delays, subjects tend to look at empty locations where the offers had previously appeared, with longer fixations increasing the probability of choosing the associated offer. Spiking activity in orbitofrontal cortex reflects the value of the gazed offer, or of the offer associated with the gazed empty spatial location, even if it is not the most recent. This reactivation reflects a reevaluation process, as fluctuations in neural spiking correlate with upcoming choice. Our results suggest that look-at-nothing gazing triggers the reactivation of a previously seen offer for further evaluation.application/pdfeng© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Escorça cerebralDecisió, Presa deAnimals -- Presa de decisionsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41467-024-50214-2info:eu-repo/semantics/openAccess