Parri, AlejandraFitó Colomer, MontserratTorres, C. F.Muñoz-Aguayo, D.Schröder, Helmut, 1958-Cano, J. F.Vázquez, Luis AlbertoReglero, G.Covas Planells, Maria Isabel2018-01-182018-01-182016Parri A, Fitó M, Torres CF, Muñoz-Aguayo D, Schröder H, Cano JF. Et al. Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals. Inflammopharmacology. 2016 Jun;24(2-3):127-31. DOI: 10.1007/s10787-016-0265-40925-4692http://hdl.handle.net/10230/33675Alkylglycerols (AKGs), isolated or present in shark liver oil have anti-inflammatory properties. Complement 3 (C3) and 4 (C4) participate in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity. In a randomized, controlled, crossover study, 26 non-diabetes obese individuals were assigned two preparations with low (LAC, 10 mg AKGs) and high (HAC, 20 mg AKGs) AKG content. Intervention periods were of 3 weeks preceded by 2-week washout periods in which shark liver oil was avoided. Cholesterol, C3, C4, and vascular endothelial growth factor (VEGF) decreased in a linear trend (P < 0.01) from baseline (control) to LAC and HAC. Values after HAC were significantly lower (P < 0.05) versus both baseline and after LAC. No adverse effects were observed or reported. Data from this pilot study open a promising field for the study of the beneficial effects of AKGs on cardiovascular risk factors in obese individuals.application/pdfeng© Elsevier http://dx.doi.org/10.1007/s10787-016-0265-4Obesitatinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s10787-016-0265-4AlkylglycerolsComplement 3Complement 4InflammationObesityVascular endothelial growth factorinfo:eu-repo/semantics/openAccess