Blume, Julia vonAlleaume, Anne-MarieKienzle, ChristineCarreras Sureda, Amado, 1986-Valverde, M. A. (Miguel Ángel), 1963-Malhotra, Vivek2014-05-082014-05-082012von Blume J, Alleaume AM, Kienzle C, Carreras-Sureda A, Valverde M, Malhotra V. Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network. J Cell Biol. 2012;199(7):1057-66. DOI: 10.1083/jcb.2012071800021-9525http://hdl.handle.net/10230/22475Ca(2+) import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca(2+) retained in the lumen of the Golgi, and what is its role in cargo sorting? We show here that a soluble, lumenal Golgi resident protein, Cab45, is required for SPCA1-dependent Ca(2+) import into the TGN; it binds secretory cargo in a Ca(2+)-dependent reaction and is required for its sorting at the TGN.application/pdfeng© Blume, Julia von et al., 2012. This article is distributed under a/nCreative Commons License Attribution–Noncommercial–Share Alike 3.0 Unported.Aparell de GolgiProteïnesinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1083/jcb.201207180info:eu-repo/semantics/openAccess