Ruvalcaba-Delgadillo, YavethMartínez Fernández, Diana EmiliaLuquin, SoniaMoreno Alcázar, AnaRedolar-Ripoll, DiegoJauregui-Huerta, FernandoFernández-Quezada, David2025-05-282025-05-282024Ruvalcaba-Delgadillo Y, Martínez-Fernández DE, Luquin S, Moreno-Alcázar A, Redolar-Ripoll D, Jauregui-Huerta F, et al. Visual EMDR stimulation mitigates acute varied stress effects on morphology of hippocampal neurons in male Wistar rats. Front Psychiatry. 2024 May 13;15:1396550. DOI: 10.3389/fpsyt.2024.13965501664-0640http://hdl.handle.net/10230/70535Introduction: Stress is a pervasive health concern known to induce physiological changes, particularly impacting the vulnerable hippocampus and the morphological integrity of its main residing cells, the hippocampal neurons. Eye Movement Desensitization and Reprocessing (EMDR), initially developed to alleviate emotional distress, has emerged as a potential therapeutic/preventive intervention for other stress-related disorders. This study aimed to investigate the impact of Acute Variable Stress (AVS) on hippocampal neurons and the potential protective effects of EMDR. Methods: Rats were exposed to diverse stressors for 7 days, followed by dendritic morphology assessment of hippocampal neurons using Golgi-Cox staining. Results: AVS resulted in significant dendritic atrophy, evidenced by reduced dendritic branches and length. In contrast, rats receiving EMDR treatment alongside stress exposure exhibited preserved dendritic morphology comparable to controls, suggesting EMDR's protective role against stressinduced dendritic remodeling. Conclusions: These findings highlight the potential of EMDR as a neuroprotective intervention in mitigating stress-related hippocampal alterations.application/pdfeng© 2024 Ruvalcaba-Delgadillo, Martínez-Fernández, Luquin, Moreno-Alcázar, Redolar-Ripoll, Jauregui-Huerta and Fernández-Quezada. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fpsyt.2024.1396550EMDRGolgi-CoxSholl analysisHippocampusStressinfo:eu-repo/semantics/openAccess