Garcia-Lunar, InésSolé-González, EduardGarcía-Álvarez, Ana2020-09-072020-09-072020Garcia-Lunar I, Blanco I, Fernández-Friera L, Prat-Gonzàlez S, Jordà P, Sánchez J. et al. Design of the β3-adrenergic agonist treatment in chronic pulmonary hypertension secondary to heart failure trial. JACC Basic Transl Sci. 2020 Mar 11; 5(4):317-327. DOI: 10.1016/j.jacbts.2020.01.0092452-302Xhttp://hdl.handle.net/10230/45260Combined pre-and post-capillary hypertension (CpcPH) is a relatively common complication of heart failure (HF) associated with a poor prognosis. Currently, there is no specific therapy approved for this entity. Recently, treatment with beta-3 adrenergic receptor (β3AR) agonists was able to improve pulmonary hemodynamics and right ventricular (RV) performance in a translational, large animal model of chronic PH. The authors present the design of a phase II randomized clinical trial that tests the benefits of mirabegron (a clinically available β3AR agonist) in patients with CpcPH due to HF. The effect of β3AR treatment will be evaluated on pulmonary hemodynamics, as well as clinical, biochemical, and advanced cardiac imaging parameters. (Beta3 Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure [SPHERE-HF]; NCT02775539).application/pdfengCopyright © 2020 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jacbts.2020.01.009CCTCardiac computed tomographyCMRCardiac magnetic resonanceCpcPHCombined pre - and post - capillary pulmonary hypertensionECGElectrocardiographyHeart failureIntention to treatIsolated post-capillary pulmonary hypertensionLeft heart diseaseLeft ventricularLeft ventricular ejection fractionN-terminal prohormone of brain natriuretic peptideNew York Heart AssociationPulmonary artery pressurePulmonary hypertensionPer protocolPulmonary vascular resistanceRight ventricleAdrenoreceptorsCyclic guanosine monophosphateImagingPulmonary hypertensionTreatmentBeta-3 adrenoreceptorinfo:eu-repo/semantics/openAccess