López-Botet, M. (Miguel)Muntasell i Castellví, Aura, 1972-Martínez-Rodriguez, José E.López-Montañés, MaríaCosta-García, MarcelPupuleku, Aldi, 1985-2017-01-112016López-Botet M, Muntasell A, Martínez-Rodríguez JE, López-Montañés M, Costa-García M, Pupuleku A. Development of the adaptive NK cell response to human cytomegalovirus in the context of aging. Mech Ageing Dev. 2016 Sep;158:23-6. DOI: 10.1016/j.mad.2016.06.0100047-6374http://hdl.handle.net/10230/27869Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. Based on epidemiological studies HCMV(+) serology has been associated with the development of atherosclerosis, immune senescence and an increase mortality rate in elderly people. Such long-term detrimental effects of the viral infection presumably result from an inefficient immune control of the pathogen, depending on the quality and evolution of the individual host-pathogen relationship. Together with antigen-specific T lymphocytes, NK cells play an important role in anti-viral immune defense. HCMV promotes in some individuals the differentiation and persistent steady state expansion of an NK cell subset bearing the CD94/NKG2C activating receptor. The relationship between this adaptive NK cell response to HCMV and aging is overviewed.application/pdfeng© Elsevier http://dx.doi.org/10.1016/j.mad.2016.06.010Envelliment -- Aspectes immunològicsCitomegalovirusDevelopment of the adaptive NK cell response to human cytomegalovirus in the context of aginginfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.mad.2016.06.010info:eu-repo/semantics/openAccess