Iribarren, CarlosLu, MengJorgenson, EricMartínez, ManuelLluís Ganella, Carla, 1984-Subirana Cachinero, IsaacSalas, EduardoElosua Llanos, Roberto2019-07-172019-07-172018Iribarren C, Lu M, Jorgenson E, Martínez M, Lluis-Ganella C, Subirana I. et al. Weighted multi-marker genetic risk scores for incident coronary heart disease among individuals of african, latino and east-asian ancestry. Sci Rep. 2018 May 1;8(1):6853. DOI: 10.1038/s41598-018-25128-x2045-2322http://hdl.handle.net/10230/42011We examined the clinical utility of two multi-locus genetic risk scores (GRSs) previously validated in Europeans among persons of African (AFR; n = 2,089), Latino (LAT; n = 4,349) and East-Asian (EA; n = 4,804) ancestry. We used data from the GERA cohort (30-79 years old, 68 to 73% female). We utilized two GRSs with 12 and 51 SNPs, respectively, and the Framingham Risk Score (FRS) to estimate 10-year CHD risk. After a median 8.7 years of follow-up, 450 incident CHD events were documented (95 in AFR, 316 in LAT and 39 EA, respectively). In a model adjusting for principal components and risk factors, tertile 3 vs. tertile 1 of GRS_12 was associated with 1.86 (95% CI, 1.15-3.01), 1.52 (95% CI, 1.02-2.25) and 1.19 (95% CI, 0.77-1.83) increased hazard of CHD in AFR, LAT and EA, respectively. Inclusion of the GRSs in models containing the FRS did not increase the C-statistic but resulted in net overall reclassification of 10% of AFR, 7% LAT and EA and in reclassification of 13% of AFR and EA as well as 10% LAT in the intermediate FRS risk subset. Our results support the usefulness of incorporating genetic information into risk assessment for primary prevention among minority subjects in the U.S.application/pdfengCopyright © The Author(s) 2018. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Malalties coronàries -- Aspectes genèticsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41598-018-25128-xinfo:eu-repo/semantics/openAccess