López Ruiz de Vargas, Sara2021-11-182021-11-182021http://hdl.handle.net/10230/49013Treball de fi de grau en Bioinformàtica. Curs 2020-2021Tutor: Trisevgeni RapakouliaWe applied an enhancer prediction method to an extensive set of epigenetic profiles from the ENCODE project. We identified enhancer elements in 104 human primary cells, cell lines, and tissues. This extensive generation of enhancer profiles allowed us to identify groups of cell types that are pretty similar in terms of enhancer usage and cell types that differ significantly. A case study on adult brain and embryo placenta tissues with quite different sets of active enhancers revealed cell-type specific enhancers that regulate the expression of genes linked to the tissue phenotype. Further exploitation of additional cell groups can reveal the lineage-specific enhancers.application/pdfengThis is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 licenseTreball de fi de grau – Curs 2020-2021Amplificació gènicaAnàlisi de dades de panelinfo:eu-repo/semantics/bachelorThesisRegulació de la transcripcióAmplificadoresAnálisis de datosRegulación de la transcripciónEnhancersData analysisTranscription regulationinfo:eu-repo/semantics/openAccess