Flores-Chávez, ACarrión Rodríguez, José AntonioForns, XavierRamos-Casals, M.2019-01-292019-01-292017Flores-Chávez A, Carrion JA, Forns X, Ramos-Casals M. et al. Extrahepatic manifestations associated with Chronic Hepatitis C Virus Infection. Rev Esp Sanid Penit. 2017 Dec;19(3):87-97. DOI: 10.4321/S1575-062020170003000041575-0620http://hdl.handle.net/10230/36448Chronic hepatitis C virus (HCV) infection has been associated with both organ-specific and systemic autoimmune diseases, with cryoglobulinemia being the most frequent associated disease. Experimental, virologic, and clinical evidence have demon-strated a close association between HCV infection and some systemic autoimmune diseases, especially Sjögren's syndrome, but also rheumatoid arthritis and lupus. A higher prevalence of hematological processes has also been described in patients with HCV infection, including cytopenias and lymphoproliferative disorders (B-cell lymphoma). In addition, patients with chronic HCV infection have a higher frequency of other extrahepatic manifestations including endocrine, metabolic and cardiovascular disorders that may worse the prognosis of patients, along with neuropsychiatric manifestations and general symptoms that have a significant influence on the quality of life of the patient. Direct-acting antiviral therapies (DAAs) that have recently begun to be used are providing the opportunity to effectively cure chronic HCV infection and reduce the burden of both hepatic and extrahepatic complications.application/pdfengLa Revista Española de Sanidad Penitenciaria es una revista Open Access, lo que quiere decir que todo su contenido es accesible libremente sin cargo para el usuario o su institución. Los usuarios están autorizados a leer, descargar, copiar, distribuir, imprimir, buscar o enlazar a los textos completos de los artículos de esta revista sin permiso previo del editor o del autor, de acuerdo con la definición BOAI de open access. La reutilización de los trabajos puede hacerse en los términos que diga la licencia Creative Commons Reconocimiento-NoComercial-SinObraDerivada 3.0 Unported License.Hepatitis Cinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.4321/S1575-06202017000300004info:eu-repo/semantics/openAccess