Ballester, Ana RosaMarcet Houben, MarinaLevin, ElenaSela, NoaSelma Lázaro, CristinaCarmona, LourdesWisniewski, MichaelDroby, SamirGonzález Candelas, LuisGabaldón Estevan, Juan Antonio, 1973-2015-11-162015-11-162015Ballester AR, Marcet-Houben M, Levin E, Sela N, Selma-Lázaro C, Carmona L et al. Genome, transcriptome, and functional analyses of penicillium expansum provide new insights into secondary metabolism and pathogenicity. Molecular plant-microbe interactions: MPMI. 2015;28(3):232-48. DOI: 10.1094/MPMI-09-14-0261-FI0894-0282http://hdl.handle.net/10230/25102The relationship between secondary metabolism and infection in pathogenic fungi has remained largely elusive. The genus Penicillium comprises a group of plant pathogens with varying host specificities and with the ability to produce a wide array of secondary metabolites. The genomes of three Penicillium expansum strains, the main postharvest pathogen of pome fruit, and one Pencillium italicum strain, a postharvest pathogen of citrus fruit, were sequenced and compared with 24 other fungal species. A genomic analysis of gene clusters responsible for the production of secondary metabolites was performed. Putative virulence factors in P. expansum were identified by means of a transcriptomic analysis of apple fruits during the course of infection. Despite a major genome contraction, P. expansum is the Penicillium species with the largest potential for the production of secondary metabolites. Results using knockout mutants clearly demonstrated that neither patulin nor citrinin are required by P. expansum to successfully infect apples. Li et al. ( MPMI-12-14-0398-FI ) reported similar results and conclusions in their recently accepted paper.application/pdfeng© The Author 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.Fongs patògensFongs -- Genèticainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1094/MPMI-09-14-0261-FIinfo:eu-repo/semantics/openAccess