Malhotra, Vivek2025-05-152025-05-152025Malhotra V. The pathways of secretory cargo export at the endoplasmic reticulum. Nat Commun. 2025 Mar 3;16(1):2138. DOI: 10.1038/s41467-025-57408-22041-1723http://hdl.handle.net/10230/70399Palade's original model proposed that secretory cargo is transported between stable compartments via vesicles. However, recent findings challenge this view, suggesting that secretory pathway compartments are dynamic, with cargo itself dictating whether transfer occurs via vesicles or through the continuity and maturation of compartmental structures. At the heart of this process is TANGO1, a key component of a molecular machine that works in concert with COPII proteins to construct export routes tailored to the size and quantity of secretory cargo.application/pdfeng© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.The pathways of secretory cargo export at the endoplasmic reticuluminfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41467-025-57408-2Cell biologyMembrane traffickinginfo:eu-repo/semantics/openAccess