Harding, Barbara N.Agramunt, SilviaPedersen, MarieKnudsen, Lisbeth E.Nielsen, Jeanette K.Wright, JohnVafeiadi, Marina, 1983-Merlo, Domenico FrancoStayner, LeslieKelly Reif, KaitlinEspinosa Díaz, AnaBustamante Pineda, MarionaGützkow, Kristine B.Granum, BeritStedingk, Hans vonRydberg, PerAlexander, JanTörnqvist, MargaretaKogevinas, Manolis2024-11-202024-11-202024Harding BN, Agramunt S, Pedersen M, Knudsen LE, Nielsen JKS, Wright J, et al. Ethylene oxide hemoglobin adducts in cord blood and offspring's size at birth: The NewGeneris european cohort study. Epidemiology. 2024 Sep 1;35(5):710-20. DOI: 10.1097/EDE.00000000000017671044-3983http://hdl.handle.net/10230/68749Background: Prenatal ethylene oxide exposure may have adverse effects on fetal development. We examined the relationships between ethylene oxide hemoglobin (Hb) adduct levels and offspring's size at birth in a prospective European mother-child study. Methods: This study included 1106 singletons from the NewGeneris project (2006-2010) with ethylene oxide Hb adducts measured in cord blood. We examined the relationships between adduct levels and offspring's size at birth among all infants and separately among infants of nonsmokers, using linear regression models for birth weight and birth head circumference and logarithmic binomial regression models for small for gestational age. We examined potential interactions between CYP2E1 single nucleotide polymorphisms in cord blood and the effects of ethylene oxide Hb adduct levels on offspring birth size. Results: Higher quartiles of adduct levels as a measure of exposure were associated with decreasing birth weight and head circumference in the overall population. Compared to infants in the lowest quartile, those in the highest quartile exhibited lower birth weight (-70.73 g, 95% confidence interval = -141.16, -0.30) and reduced head circumference (-0.30 cm, 95% confidence interval = -0.58, -0.02). We observed similar, albeit less pronounced, patterns among infants of nonsmokers. There was no evidence of an association between ethylene oxide Hb adducts and risk of small for gestational age, nor consistent evidence of an interaction with CYP2E1 polymorphisms on the association between EO Hb adduct levels and offspring's size at birth.application/pdfeng© 2024 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/articlehttp://dx.doi.org/10.1097/EDE.0000000000001767BiomarkerBirth outcomesBirth weightEthylene oxideHead circumferenceHemoglobin adductsinfo:eu-repo/semantics/openAccess