Baré, MarisaLleal, MarinaSevilla-Sánchez, DanielOrtonobes, SaraHerranz, SusanaFernández, OliviaCorral-Vázquez, CeliaMolist, NúriaNazco, Gloria JuliaMartín-González, CandelariaMárquez, Miguel ÁngelMoPIM study group2024-05-022024-05-022023Baré M, Lleal M, Sevilla-Sánchez D, Ortonobes S, Herranz S, Ferrandez O, et al. Sex differences in multimorbidity, inappropriate medication and adverse outcomes of inpatient care: MoPIM cohort study. Int J Environ Res Public Health. 2023 Feb 18;20(4):3639. DOI: 10.3390/ijerph200436391660-4601http://hdl.handle.net/10230/59973There is no published evidence on the possible differences in multimorbidity, inappropriate prescribing, and adverse outcomes of care, simultaneously, from a sex perspective in older patients. We aimed to identify those possible differences in patients hospitalized because of a chronic disease exacerbation. A multicenter, prospective cohort study of 740 older hospitalized patients (≥65 years) was designed, registering sociodemographic variables, frailty, Barthel index, chronic conditions (CCs), geriatric syndromes (GSs), polypharmacy, potentially inappropriate prescribing (PIP) according to STOPP/START criteria, and adverse drug reactions (ADRs). Outcomes were length of stay (LOS), discharge to nursing home, in-hospital mortality, cause of mortality, and existence of any ADR and its worst consequence. Bivariate analyses between sex and all variables were performed, and a network graph was created for each sex using CC and GS. A total of 740 patients were included (53.2% females, 53.5% ≥85 years old). Women presented higher prevalence of frailty, and more were living in a nursing home or alone, and had a higher percentage of PIP related to anxiolytics or pain management drugs. Moreover, they presented significant pairwise associations between CC, such as asthma, vertigo, thyroid diseases, osteoarticular diseases, and sleep disorders, and with GS, such as chronic pain, constipation, and anxiety/depression. No significant differences in immediate adverse outcomes of care were observed between men and women in the exacerbation episode.application/pdfeng© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/ijerph20043639Sex perspectiveMultimorbidityNetwork analysisPotentially inappropriate medicationAdverse drug reactionIn-hospital mortalityOutcomes of careinfo:eu-repo/semantics/openAccess