Oliveras, AnnaGoday Arno, AlbertoSans Atxer, LaiaVázquez, SusanaBenaiges Foix, DavidRamón Moros, José ManuelPascual Santos, Julio2020-03-242020Oliveras A, Goday A, Sans L, Arias CE, Vazquez S, Benaiges D, et al. Changes in central 24-h ambulatory blood pressure and hemodynamics 12 months after bariatric surgery: the BARIHTA study. Obes Surg. 2020 Jan; 30(1):195-205. DOI: 10.1007/s11695-019-04107-90960-8923http://hdl.handle.net/10230/44003Background: Weight loss is associated to blood pressure (BP) reduction in obese patients. There is no information on central 24-h BP changes after bariatric surgery (BS). Methods and results: In this study, we analyzed changes in 24-h BP 12 months following BS, with intermediate evaluations at 1, 3, and 6 months, in severely obese adults. The primary endpoint was aortic (central) 24-h systolic BP changes. Circadian BP patterns and hypertension resolution were also assessed. As secondary endpoints, we analyze changes in central 24-h diastolic BP as well as in all office and ambulatory peripheral BP parameters. Obese adults scheduled for BS as routine clinical care were recruited. We included 62 patients (39% with hypertension, 77% women, body mass index, 42.6 ± 5.5 kg/m2). Reduction in body weight was mean (IQR) 30.5% (26.2-34.4) 1 year after BS. Mean (95% CI) change in central 24-h systolic BP was - 3.1 mmHg (- 5.5 to - 0.7), p = 0.01 after adjustment for age, sex, and baseline hypertensive status. BP parameter changes were different between normotensives and hypertensives. Mean (95% CI) change in central 24-h systolic BP was - 5.2 mmHg (- 7.7 to - 2.7), p < 0.001, in normotensives and - 0.5 mmHg (- 5.1 to 4.0), p = 0.818, in hypertensives. There was a remission of hypertension in 48% of patients. Most patients had a reduced dipping pattern, similarly at baseline and 12 months after BS. Conclusions: Among patients with severe obesity, there was a substantial central 24-h systolic BP decrease 12 months following BS. Importantly, this change was observed in those patients with normal BP at baseline.application/pdfeng© Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s11695-019-04107-9info:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s11695-019-04107-9Arterial stiffnessBariatric surgeryCardiac outputCentral blood pressureObesityinfo:eu-repo/semantics/openAccess